LOCUS SIU01143.1 185 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE OXIDASE REGULATORY-RELATED PROTEIN protein. ACCESSION LT708304-2557 PROTEIN_ID SIU01143.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2527C" /note="Mb2527c, -, len: 185 aa. Equivalent to Rv2499c, len: 185 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 185 aa overlap). Possible oxidase regulatory-related protein, similar to many maoC MONOAMINE OXIDASE REGULATORY PROTEIN e.g. Q9RUZ1|DR1239 MAOC-RELATED PROTEIN from Deinococcus radiodurans (160 aa), FASTA scores: opt: 519, E(): 7.6e-28, (58.1% identity in 148 aa overlap); BAB48392|MLR0905 Probable monoamine oxidase regulatory protein from Rhizobium loti (Mesorhizobium loti) (150 aa), FASTA scores: opt: 480, E(): 2.9e-25, (49.0% identity in 149 aa overlap); Q9HN18|MAOC1|VNG2290G MONOAMINE OXIDASE REGULATORY-LIKE from Halobacterium sp. strain NRC-1 (208 aa), FASTA scores: opt: 419, E(): 4.6e-21, (45.6% identity in 158 aa overlap); P77455|MAOC_ECOLI|PAAZ|B1387 MaoC protein (Phenylacetic acid degradation protein paaZ) from Escherichia coli strain K12 (681 aa), FASTA scores: opt: 252, E(): 1.9e-09, (36.0% identity in 172 aa overlap); etc. But also similar to other proteins with different putative functions e.g. Q9HRM9|MAOC2|VNG0626G MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN from Halobacterium sp strain NRC-1 (157 aa), FASTA scores: opt: 380, E(): 1.5e-18, (45.75% identity in 153 aa overlap); Q9KIF1 FKBR2 from Streptomyces hygroscopicus var. ascomyceticus (175 aa), FASTA scores: opt: 355, E(): 7.6e-17, (42.0% identity in 150 aa overlap); CAC36828|Q99Q03|SAPE Spore associated protein from Streptomyces coelicolor (174 aa), FASTA scores: opt: 318, E(): 2.2e-14, (41.45% identity in 152 aa overlap); etc. Protein product from Mb2527c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2527c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1E5" BEGIN 1 MTKHAGDRES DDAVSACRVA GSTVGRRILQ RGLWFEEFQI GTTYLHRPGR TVTEADNVLF 61 TTLTMNTQSL HLDAAWAGQQ PGFRGERLVN SMFTLSTMVG LSVAQLTLGT IVANLGFSEV 121 SFPKPVFHGD TLYAETVCTG KRESKSRPGE GIVTLEHIAR NQHGEVVARA VRTTLVQKQS 181 IKEAQ //