LOCUS       SIU01142.1               273 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CITRATE (PRO-3S)-LYASE (BETA SUBUNIT) CITE (CITRASE) (
            CITRATASE) (CITRITASE) (CITRIDESMOLASE) (CITRASE ALDOLASE)
            protein.
ACCESSION   LT708304-2556
PROTEIN_ID  SIU01142.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="citE"
                     /locus_tag="BQ2027_MB2526C"
                     /note="Mb2526c, citE, len: 273 aa. Equivalent to Rv2498c,
                     len: 273 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 273 aa overlap). Probable citE,
                     citrate lyase, beta subunit (EC 4.1.3.6), similar to
                     others e.g. Q9S3L3|CITE from Corynebacterium glutamicum
                     (Brevibacterium flavum) (217 aa), FASTA scores: opt: 565,
                     E(): 1.5e-28, (41.85% identity in 215 aa overlap);
                     Q9HRM8|CITE|VNG0627G from Halobacterium sp. strain NRC-1
                     (303 aa), FASTA scores: opt: 535, E(): 1.5e-26, (41.65%
                     identity in 276 aa overlap); Q9S2U9|SC4G6.02 from
                     Streptomyces coelicolor (274 aa), FASTA scores: opt: 426,
                     E(): 1e-19, (37.6% identity in 274 aa overlap);
                     P77770|CILB_ECOLI from Escherichia coli (307 aa), FASTA
                     scores: opt: 265, E(): 1.5e-10, (32.8% identity in 265 aa
                     overlap); etc. Also similar to Rv3075c|MTCY22D7.06 from
                     Mycobacterium tuberculosis, FASTA score: (35.2% identity
                     in 264 aa overlap). Protein product from Mb2526c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2526c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1E1"
                     /db_xref="InterPro:IPR005000"
                     /db_xref="InterPro:IPR011206"
                     /db_xref="InterPro:IPR015813"
                     /db_xref="InterPro:IPR040442"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1E1"
BEGIN
        1 MNLRAAGPGW LFCPADRPER FAKAAAAADV VILDLEDGVA EAQKPAARNA LRDTPLDPER
       61 TVVRINAGGT ADQARDLEAL AGTAYTTVML PKAESAAQVI ELAPRDVIAL VETARGAVCA
      121 AEIAAADPTV GMMWGAEDLI ATLGGSSSRR ADGAYRDVAR HVRSTILLAA SAFGRLALDA
      181 VHLDILDVEG LQEEARDAAA VGFDVTVCIH PSQIPVVRKA YRPSHEKLAW ARRVLAASRS
      241 ERGAFAFEGQ MVDSPVLTHA ETMLRRAGEA TSE
//