LOCUS SIU01140.1 348 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable branched-chain keto acid dehydrogenase e1 component, beta subunit bkdb protein. ACCESSION LT708304-2554 PROTEIN_ID SIU01140.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="bkdb" /locus_tag="BQ2027_MB2524C" /note="Mb2524c, pdhB, len: 348 aa. Equivalent to Rv2496c, len: 348 aa, from Mycobacterium tuberculosis strain H37Rv, (99.7% identity in 348 aa overlap). Probable pdhB, pyruvate dehydrogenase e1 component, beta subunit (EC 1.2.4.1), similar to others e.g. Q9Y8I6||PDHB from Halobacterium volcanii (Haloferax volcanii) (327 aa) FASTA scores: opt: 1050, E(): 6.4e-60, (49.7% identity in 324 aa overlap); Q9KG98|BH0214 from Bacillus halodurans (328 aa), FASTA scores: opt: 987, E(): 6.9e-56, (45.7% identity in 324 aa overlap); Q9HN76|PDHB|VNG2218G from Halobacterium sp. strain NRC-1 (297 aa), FASTA scores: opt: 968, E(): 1.1e-54, (51.2% identity in 297 aa overlap); P21874|ODPB_BACST|PDHB PYRUVATE DEHYDROGENASE E1 COMPONENT from Bacillus stearothermophilus (324 aa), FASTA scores: opt: 951, E(): 1.4e-53, (47.6% identity in 321 aa overlap); etc. Also similar to Q9XA61|SCGD3.17c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1, BETA SUBUNIT (2-oxoisovalerate dehydrogenase) (EC 1.2.4.4) from Streptomyces coelicolor, (326 aa), FASTA scores: opt: 1178, E(): 4.1e-68, (55.0% identity in 322 aa overlap); Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1 BETA SUBUNIT from Streptomyces coelicolor (334 aa), FASTA scores: opt: 1173, E(): 8.8e-68, (55.6% identity in 320 aa overlap); Q53593|BKDB E1-BETA BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE from Streptomyces avermitilis (334 aa), FASTA scores: opt: 1132, E(): 3.7e-65, (55.0% identity in 320 aa overlap); etc. Protein product from Mb2524c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2524c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y1E4" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1E4" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MTQIADRPAR PDETLAVAVS DITQSLTMVQ AINRALYDAM AADERVLVFG EDVAVEGGVF 61 RVTEGLADTF GADRCFDTPL AESAIIGIAV GLALRGFVPV PEIQFDGFSY PAFDQVVSHL 121 AKYRTRTRGE VDMPVTVRIP SFGGIGAAEH HSDSTESYWV HTAGLKVVVP STPGDAYWLL 181 RHAIACPDPV MYLEPKRRYH SRGMVDTSRP EPPIGHAMVR RSGTDVTVVT YGNLVSTALS 241 SADTAEQQHD WSLEVIDLRS LAPLDFDTIA ASIQRTGRCV VMHEGPRSLG YGAGLAARIQ 301 EEMFYQLEAP VLRACGFDTP YPPARLEKLW LPGPDRLLDC VERVLRQP //