LOCUS       SIU01140.1               348 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            branched-chain keto acid dehydrogenase e1 component, beta
            subunit bkdb protein.
ACCESSION   LT708304-2554
PROTEIN_ID  SIU01140.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="bkdb"
                     /locus_tag="BQ2027_MB2524C"
                     /note="Mb2524c, pdhB, len: 348 aa. Equivalent to Rv2496c,
                     len: 348 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 348 aa overlap). Probable pdhB,
                     pyruvate dehydrogenase e1 component, beta subunit (EC
                     1.2.4.1), similar to others e.g. Q9Y8I6||PDHB from
                     Halobacterium volcanii (Haloferax volcanii) (327 aa) FASTA
                     scores: opt: 1050, E(): 6.4e-60, (49.7% identity in 324 aa
                     overlap); Q9KG98|BH0214 from Bacillus halodurans (328 aa),
                     FASTA scores: opt: 987, E(): 6.9e-56, (45.7% identity in
                     324 aa overlap); Q9HN76|PDHB|VNG2218G from Halobacterium
                     sp. strain NRC-1 (297 aa), FASTA scores: opt: 968, E():
                     1.1e-54, (51.2% identity in 297 aa overlap);
                     P21874|ODPB_BACST|PDHB PYRUVATE DEHYDROGENASE E1 COMPONENT
                     from Bacillus stearothermophilus (324 aa), FASTA scores:
                     opt: 951, E(): 1.4e-53, (47.6% identity in 321 aa
                     overlap); etc. Also similar to Q9XA61|SCGD3.17c PUTATIVE
                     BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE E1, BETA
                     SUBUNIT (2-oxoisovalerate dehydrogenase) (EC 1.2.4.4) from
                     Streptomyces coelicolor, (326 aa), FASTA scores: opt:
                     1178, E(): 4.1e-68, (55.0% identity in 322 aa overlap);
                     Q9XA48|SCGD3.31c PUTATIVE BRANCHED-CHAIN ALPHA KETO ACID
                     DEHYDROGENASE E1 BETA SUBUNIT from Streptomyces coelicolor
                     (334 aa), FASTA scores: opt: 1173, E(): 8.8e-68, (55.6%
                     identity in 320 aa overlap); Q53593|BKDB E1-BETA
                     BRANCHED-CHAIN ALPHA KETO ACID DEHYDROGENASE from
                     Streptomyces avermitilis (334 aa), FASTA scores: opt:
                     1132, E(): 3.7e-65, (55.0% identity in 320 aa overlap);
                     etc. Protein product from Mb2524c detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb2524c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y1E4"
                     /db_xref="InterPro:IPR005475"
                     /db_xref="InterPro:IPR009014"
                     /db_xref="InterPro:IPR029061"
                     /db_xref="InterPro:IPR033248"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1E4"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTQIADRPAR PDETLAVAVS DITQSLTMVQ AINRALYDAM AADERVLVFG EDVAVEGGVF
       61 RVTEGLADTF GADRCFDTPL AESAIIGIAV GLALRGFVPV PEIQFDGFSY PAFDQVVSHL
      121 AKYRTRTRGE VDMPVTVRIP SFGGIGAAEH HSDSTESYWV HTAGLKVVVP STPGDAYWLL
      181 RHAIACPDPV MYLEPKRRYH SRGMVDTSRP EPPIGHAMVR RSGTDVTVVT YGNLVSTALS
      241 SADTAEQQHD WSLEVIDLRS LAPLDFDTIA ASIQRTGRCV VMHEGPRSLG YGAGLAARIQ
      301 EEMFYQLEAP VLRACGFDTP YPPARLEKLW LPGPDRLLDC VERVLRQP
//