LOCUS       SIU01130.1               206 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PE-
            PGRS FAMILY PROTEIN [FIRST PART] protein.
ACCESSION   LT708304-2544
PROTEIN_ID  SIU01130.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PE_PGRS42a"
                     /locus_tag="BQ2027_MB2514C"
                     /note="Mb2514c, PE_PGRS42a, len: 206 aa. Similar to 5' end
                     of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100.0% identity in 136 aa overlap). Member
                     of the Mycobacterium tuberculosis PE family, PGRS
                     subfamily of Gly-rich proteins, similar to many e.g.
                     AAK47245|MT2919 PE_PGRS family protein from M.
                     tuberculosis strain CDC1515 (663 aa), FASTA scores: opt:
                     2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap);
                     etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, PE_PGRS42 exists as a single
                     gene. In Mycobacterium bovis, 2 frameshifts, the first due
                     to a single base insertion (*-c) and the second due to a
                     single base deletion (g-*) splits PE_PGRS42 into 3 parts,
                     PE_PGRS42a and PE_PGRS42b and PE_PGRS42d."
                     /db_xref="InterPro:IPR000084"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1D3"
BEGIN
        1 MSLVIATPQL LATAALDLAS IGSQVSAANA AAAMPTTEVV AAAADEVSAA IAGLFGAHAR
       61 QYQALSVQVA AFHEQFVQAL TAAAGRYAST EAAVERSLLG AVNAPTEALL GRPLIGNGAD
      121 GTAPGQPGAA GGLLFGQRWQ RRGWRVRSNR RQRRRGRVDR QRRQRRGRWY RRGRRCRWER
      181 GVVVGQRRQR RCRRHQRGRR HRGCGR
//