LOCUS SIU01130.1 206 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PE- PGRS FAMILY PROTEIN [FIRST PART] protein. ACCESSION LT708304-2544 PROTEIN_ID SIU01130.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="PE_PGRS42a" /locus_tag="BQ2027_MB2514C" /note="Mb2514c, PE_PGRS42a, len: 206 aa. Similar to 5' end of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 136 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from M. tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d." /db_xref="InterPro:IPR000084" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1D3" BEGIN 1 MSLVIATPQL LATAALDLAS IGSQVSAANA AAAMPTTEVV AAAADEVSAA IAGLFGAHAR 61 QYQALSVQVA AFHEQFVQAL TAAAGRYAST EAAVERSLLG AVNAPTEALL GRPLIGNGAD 121 GTAPGQPGAA GGLLFGQRWQ RRGWRVRSNR RQRRRGRVDR QRRQRRGRWY RRGRRCRWER 181 GVVVGQRRQR RCRRHQRGRR HRGCGR //