LOCUS       SIU01129.1               315 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PE-
            PGRS FAMILY PROTEIN [SECOND PART] protein.
ACCESSION   LT708304-2543
PROTEIN_ID  SIU01129.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="PE_PGRS42b"
                     /locus_tag="BQ2027_MB2513C"
                     /note="Mb2513c, PE_PGRS42b, len: 315 aa. Similar to middle
                     section of Rv2487c, len: 694 aa, from Mycobacterium
                     tuberculosis strain H37Rv, (99.3% identity in 284 aa
                     overlap). Member of the Mycobacterium tuberculosis PE
                     family, PGRS subfamily of Gly-rich proteins, similar to
                     many e.g. AAK47245|MT2919 PE_PGRS family protein from
                     Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA
                     scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622
                     aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists
                     as a single gene. In Mycobacterium bovis, 2 frameshifts,
                     the first due to a single base insertion (*-c) and the
                     second due to a single base deletion (g-*) splits
                     PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and
                     PE_PGRS42d."
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1A8"
BEGIN
        1 MFGHGGAGGT GGAGLAGANG VNPTPGPAAS TGDSPADVSG IGDQTGGDGG TGGHGTAGTP
       61 TGGTGGDGAT ATAGSGKATG GAGGDGGTAA AGGGGGNGGD GGVAQGDIAS AFGGDGGNGS
      121 DGVAAGSGGG SGGAGGGAFV HIVTATSTGG SGGFGGNGAA SAASGADGGA GGAGGNGGAG
      181 GLLFGDGGNG GAGGAGGIGG DGATGGPGEA AATLASRGLT AQTPRQNPMW SAARVVMAAR
      241 AAAALASAAP AGPAARAATA APAGCCSATA ATAATPGPAG MAAPALPVGL AVTAAVVAPR
      301 RFTKTRSLVS GRSVA
//