LOCUS SIU01129.1 315 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PE- PGRS FAMILY PROTEIN [SECOND PART] protein. ACCESSION LT708304-2543 PROTEIN_ID SIU01129.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="PE_PGRS42b" /locus_tag="BQ2027_MB2513C" /note="Mb2513c, PE_PGRS42b, len: 315 aa. Similar to middle section of Rv2487c, len: 694 aa, from Mycobacterium tuberculosis strain H37Rv, (99.3% identity in 284 aa overlap). Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of Gly-rich proteins, similar to many e.g. AAK47245|MT2919 PE_PGRS family protein from Mycobacterium tuberculosis strain CDC1515 (663 aa), FASTA scores: opt: 2317, E(): 2.3e-84, (58.35% identity in 622 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, PE_PGRS42 exists as a single gene. In Mycobacterium bovis, 2 frameshifts, the first due to a single base insertion (*-c) and the second due to a single base deletion (g-*) splits PE_PGRS42 into 3 parts, PE_PGRS42a and PE_PGRS42b and PE_PGRS42d." /db_xref="UniProtKB/TrEMBL:A0A1R3Y1A8" BEGIN 1 MFGHGGAGGT GGAGLAGANG VNPTPGPAAS TGDSPADVSG IGDQTGGDGG TGGHGTAGTP 61 TGGTGGDGAT ATAGSGKATG GAGGDGGTAA AGGGGGNGGD GGVAQGDIAS AFGGDGGNGS 121 DGVAAGSGGG SGGAGGGAFV HIVTATSTGG SGGFGGNGAA SAASGADGGA GGAGGNGGAG 181 GLLFGDGGNG GAGGAGGIGG DGATGGPGEA AATLASRGLT AQTPRQNPMW SAARVVMAAR 241 AAAALASAAP AGPAARAATA APAGCCSATA ATAATPGPAG MAAPALPVGL AVTAAVVAPR 301 RFTKTRSLVS GRSVA //