LOCUS       SIU01106.1               268 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            DNA GLYCOSYLASE protein.
ACCESSION   LT708304-2520
PROTEIN_ID  SIU01106.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2491C"
                     /note="Mb2491c, -, len: 268 aa. Equivalent to Rv2464c,
                     len: 268 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 268 aa overlap). Possible DNA
                     glycosylase (EC 3.2.2.-), showing some similarity to
                     several other DNA glycosylases e.g. Q9F308|SCC80.11c
                     PUTATIVE DNA REPAIR HYDROLASE (FRAGMENT) from Streptomyces
                     coelicolor (306 aa), FASTA scores: opt: 894, E(): 6.1e-51,
                     (51.05% identity in 282 aa overlap); O50606|MUTM|FPG_THETH
                     FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE (EC 3.2.2.23) from
                     Thermus aquaticus (267 aa), FASTA scores: opt: 342, E():
                     4.6e-15, (32.4% identity in 250 aa overlap);
                     Q9RCW5|SCM10.34c PUTATIVE FORMAMIDOPYRIMIDINE-DNA
                     GLYCOSYLASE from Streptomyces coelicolor (287 aa), FASTA
                     scores: opt: 321, E(): 1.1e-13, (29.35% identity in 259 aa
                     overlap); etc. Identical to AAK46839|MT2539
                     FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE from Mycobacterium
                     tuberculosis strain CDC1551. Also similar to other M.
                     tuberculosis DNA glycosylases e.g. MTCY71.37 (32.9%
                     identity in 277 aa overlap). BELONGS TO THE FPG FAMILY.
                     Protein product from Mb2491c detected using SWATH mass
                     spectrometry. Mb2491c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P64159"
                     /db_xref="InterPro:IPR000214"
                     /db_xref="InterPro:IPR010663"
                     /db_xref="InterPro:IPR010979"
                     /db_xref="InterPro:IPR012319"
                     /db_xref="InterPro:IPR015886"
                     /db_xref="InterPro:IPR015887"
                     /db_xref="InterPro:IPR035937"
                     /db_xref="UniProtKB/Swiss-Prot:P64159"
BEGIN
        1 MPEGHTLHRL ARLHQRRFAG APVSVSSPQG RFADSASALN GRVLRRASAW GKHLFHHYVG
       61 GPVVHVHLGL YGTFTEWARP TDGWLPEPAG QVRMRMVGAE FGTDLRGPTV CESIDDGEVA
      121 DVVARLGPDP LRSDANPSSA WSRITKSRRP IGALLMDQTV IAGVGNVYRN ELLFRHRIDP
      181 QRPGRGIGEP EFDAAWNDLV SLMKVGLRRG KIIVVRPEHD HGLPSYLPDR PRTYVYRRAG
      241 EPCRVCGGVI RTALLEGRNV FWCPVCQT
//