LOCUS       SIU01104.1               466 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRIGGER FACTOR (TF) PROTEIN TIG protein.
ACCESSION   LT708304-2518
PROTEIN_ID  SIU01104.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="tig"
                     /locus_tag="BQ2027_MB2489C"
                     /note="Mb2489c, tig, len: 466 aa. Equivalent to Rv2462c,
                     len: 466 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 466 aa overlap). Probable tig, trigger
                     factor (TF), a chaperone protein, equivalent to
                     Q9CBY2|ML1481 POSSIBLE MOLECULAR CHAPERONE from
                     Mycobacterium leprae (469 aa), FASTA scores: opt: 2171,
                     E(): 7.2e-113, (70.1% identity in 468 aa overlap). Also
                     similar to oyher trigger factors from several organisms
                     e.g. Q9F314|SCC80.05c from Streptomyces coelicolor (468
                     aa), FASTA scores: opt: 1224, E(): 1.7e-60, (41.8%
                     identity in 469 aa overlap); Q9K8F3|TIG_BACHD from
                     Bacillus halodurans (431 aa), FASTA scores: opt: 675, E():
                     3.6e-30, (28.5% identity in 421 aa overlap);
                     P22257|TIG_ECOLI from Escherichia coli (432 aa), FASTA
                     scores: opt: 493, E(): 4.2e-20, (23.35% identity in 433 aa
                     overlap); etc. BELONGS TO THE FKBP-TYPE PPIASE FAMILY, TIG
                     SUBFAMILY. Protein product from Mb2489c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb2489c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:Q7TYJ1"
                     /db_xref="InterPro:IPR005215"
                     /db_xref="InterPro:IPR008880"
                     /db_xref="InterPro:IPR008881"
                     /db_xref="InterPro:IPR027304"
                     /db_xref="InterPro:IPR036611"
                     /db_xref="InterPro:IPR037041"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TYJ1"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MKSTVEQLSP TRVRINVEVP FAELEPDFQR AYKELAKQVR LPGFRPGKAP AKLLEARIGR
       61 EAMLDQIVND ALPSRYGQAV AESDVQPLGR PNIEVTKKEY GQDLQFTAEV DIRPKISLPD
      121 LSALTVSVDP IEIGEDDVDA ELQSLRTRFG TLTAVDRPVA VGDVVSIDLS ATVDGEDIPN
      181 AAAEGLSHEV GSGRLIAGLD DAVVGLSADE SRVFTAKLAA GEHAGQEAQV TVTVRSVKER
      241 ELPEPDDEFA QLASEFDSID ELRASLSDQV RQAKRAQQAE QIRNATIDAL LEQVDVPLPE
      301 SYVQAQFDSV LHSALSGLNH DEARFNELLV EQGSSRAAFD AEARTASEKD VKRQLLLDAL
      361 ADELQVQVGQ DDLTERLVTT SRQYGIEPQQ LFGYLQERNQ LPTMFADVRR ELAIRAAVEA
      421 ATVTDSDGNT IDTSEFFGKR VSAGEAEEAE PADEGAARAA SDEATT
//