LOCUS       SIU01089.1               487 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-
            GLUTAMATE SYNTHETASE) (FPGS) protein.
ACCESSION   LT708304-2503
PROTEIN_ID  SIU01089.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="folC"
                     /locus_tag="BQ2027_MB2474C"
                     /note="Mb2474c, folC, len: 487 aa. Equivalent to Rv2447c,
                     len: 487 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 487 aa overlap). Probable folC,
                     folylpolyglutamate synthase (EC 6.3.2.17), equivalent to
                     Q9CBY8|FOLC|ML1471 from Mycobacterium leprae (485 aa),
                     FASTA scores: opt: 2425, E(): 2.2e-134, (78.7% identity in
                     483 aa overlap). Also highly similar to others e.g.
                     Q9L1G4|FPGS|O08416|Y13070 from Streptomyces coelicolor
                     (444 aa), FASTA scores: opt: 774, E(): 6.3e-38, (53.9%
                     identity in 462 aa overlap); P15925|FOLC_LACCA|FGS from
                     Lactobacillus casei (428 aa), FASTA scores: opt: 631, E():
                     1.4e-29, (34.55% identity in 437 aa overlap);
                     Q05865|FOLC_BACSU from Bacillus subtilis (430 aa), FASTA
                     scores: opt: 421, E(): 2.6e-17, (32.9% identity in 383 aa
                     overlap); etc. Contains PS01012 Folylpolyglutamate
                     synthase signature 2. BELONGS TO THE FOLYLPOLYGLUTAMATE
                     SYNTHASE FAMILY. Protein product from Mb2474c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2474c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y188"
                     /db_xref="InterPro:IPR001645"
                     /db_xref="InterPro:IPR004101"
                     /db_xref="InterPro:IPR013221"
                     /db_xref="InterPro:IPR018109"
                     /db_xref="InterPro:IPR036565"
                     /db_xref="InterPro:IPR036615"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y188"
BEGIN
        1 MNSTNSGPPD SGSATGVVPT PDEIASLLQV EHLLDQRWPE TRIDPSLTRI SALMDLLGSP
       61 QRSYPSIHIA GTNGKTSVAR MVDALVTALH RRTGRTTSPH LQSPVERISI DGKPISPAQY
      121 VATYREIEPL VALIDQQSQA SAGKGGPAMS KFEVLTAMAF AAFADAPVDV AVVEVGMGGR
      181 WDATNVINAP VAVITPISID HVDYLGADIA GIAGEKAGII TRAPDGSPDT VAVIGRQVPK
      241 VMEVLLAESV RADASVARED SEFAVLRRQI AVGGQVLQLQ GLGGVYSDIY LPLHGEHQAH
      301 NAVLALASVE AFFGAGAQRQ LDGDAVRAGF AAVTSPGRLE RMRSAPTVFI DAAHNPAGAS
      361 ALAQTLAHEF DFRFLVGVLS VLGDKDVDGI LAALEPVFDS VVVTHNGSPR ALDVEALALA
      421 AGERFGPDRV RTAENLRDAI DVATSLVDDA AADPDVAGDA FSRTGIVITG SVVTAGAART
      481 LFGRDPQ
//