LOCUS SIU01089.1 487 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA- GLUTAMATE SYNTHETASE) (FPGS) protein. ACCESSION LT708304-2503 PROTEIN_ID SIU01089.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="folC" /locus_tag="BQ2027_MB2474C" /note="Mb2474c, folC, len: 487 aa. Equivalent to Rv2447c, len: 487 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 487 aa overlap). Probable folC, folylpolyglutamate synthase (EC 6.3.2.17), equivalent to Q9CBY8|FOLC|ML1471 from Mycobacterium leprae (485 aa), FASTA scores: opt: 2425, E(): 2.2e-134, (78.7% identity in 483 aa overlap). Also highly similar to others e.g. Q9L1G4|FPGS|O08416|Y13070 from Streptomyces coelicolor (444 aa), FASTA scores: opt: 774, E(): 6.3e-38, (53.9% identity in 462 aa overlap); P15925|FOLC_LACCA|FGS from Lactobacillus casei (428 aa), FASTA scores: opt: 631, E(): 1.4e-29, (34.55% identity in 437 aa overlap); Q05865|FOLC_BACSU from Bacillus subtilis (430 aa), FASTA scores: opt: 421, E(): 2.6e-17, (32.9% identity in 383 aa overlap); etc. Contains PS01012 Folylpolyglutamate synthase signature 2. BELONGS TO THE FOLYLPOLYGLUTAMATE SYNTHASE FAMILY. Protein product from Mb2474c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2474c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y188" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="UniProtKB/TrEMBL:A0A1R3Y188" BEGIN 1 MNSTNSGPPD SGSATGVVPT PDEIASLLQV EHLLDQRWPE TRIDPSLTRI SALMDLLGSP 61 QRSYPSIHIA GTNGKTSVAR MVDALVTALH RRTGRTTSPH LQSPVERISI DGKPISPAQY 121 VATYREIEPL VALIDQQSQA SAGKGGPAMS KFEVLTAMAF AAFADAPVDV AVVEVGMGGR 181 WDATNVINAP VAVITPISID HVDYLGADIA GIAGEKAGII TRAPDGSPDT VAVIGRQVPK 241 VMEVLLAESV RADASVARED SEFAVLRRQI AVGGQVLQLQ GLGGVYSDIY LPLHGEHQAH 301 NAVLALASVE AFFGAGAQRQ LDGDAVRAGF AAVTSPGRLE RMRSAPTVFI DAAHNPAGAS 361 ALAQTLAHEF DFRFLVGVLS VLGDKDVDGI LAALEPVFDS VVVTHNGSPR ALDVEALALA 421 AGERFGPDRV RTAENLRDAI DVATSLVDDA AADPDVAGDA FSRTGIVITG SVVTAGAART 481 LFGRDPQ //