LOCUS       SIU01076.1               730 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            cyclase (adenylyl-or guanylyl-)(adenylate-or guanylate-
            ) protein.
ACCESSION   LT708304-2490
PROTEIN_ID  SIU01076.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2461C"
                     /note="Mb2461c, -, len: 730 aa. Equivalent to Rv2435c,
                     len: 730 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 730 aa overlap). Probably a cyclase
                     (adenylyl- or guanylyl-cyclase; EC 4.6.1.1 or 4.6.1.2
                     respectively); C-terminal domain (aa 500-730) similar to
                     domain at C-terminus of a series of adenylate/guanylate
                     cyclases (EC 4.6.-.-) e.g. O30820|CYA AAK45931|MT1661 from
                     Mycobacterium tuberculosis (443 aa) FASTA scores: opt:
                     446, E(): 1.3e-19, (30.55% identity in 301 aa overlap);
                     BAB50179|MLL3242 CYCLASE (ADENYLYL OR GUANYLYL) from
                     Rhizobium loti (356 aa), FASTA scores: opt: 372, E():
                     3.4e-15, (28.75% identity in 219 aa overlap); etc. BELONGS
                     TO ADENYLYL CYCLASE CLASS-4/GUANYLYL CYCLASE FAMILY.
                     Mb2461c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y1E6"
                     /db_xref="InterPro:IPR001054"
                     /db_xref="InterPro:IPR003660"
                     /db_xref="InterPro:IPR029787"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1E6"
BEGIN
        1 MTSGEALDSV AESESTPAKK RHKNVLRRRP RFRASIQSKL MVLLLLTSIV SVAAIAAIVY
       61 QSGRTSLRAA AYERLTQLRE SQKRAVETLF SDLTNSLVIY ERGLTVVDAV VRFTAGFDQL
      121 ADATISPAQQ QAIVNYYNNE FITPVERTTG DKLDITALLP TSPAQRYLQA YYTAPFTSDQ
      181 DAMRLDDAGD GSAWSAANAQ FNSYFREIVT RFDYDDAVLL DTRGNIVYTL SKDPDLGTNI
      241 LTGPYRESNL RDAYLKALGA NAVDFTWITD FKPYQPQLGV PTAWLVAPVE AGGKTQGVLA
      301 LPLPIDKINK IMTADRQWQA AGMGSGTETY LAGPDSLMRS DSRLFLQDPE EYRKQVVAAG
      361 TSLDVVNRAI QFGGTTLLQP VATEGLRAAQ RGQTGTVTST DYTGSRELEA YAPLNVPDSD
      421 LHWSILATRN DSEAFAAVAS FSRALVLVTV GIIVVICVAS MLIAHAMVRP IRRLEVGTQK
      481 ISAGDYEVNI PVKSRDEIGD LTAAFNEMSR NLQTKEELLN EQRKENDRLL LSMMPEPVVE
      541 RYRLGEQTIA QEHQDVTVLF ADILGVDEIS SGLSGNELVK IVDELVRQFD SAAEHLGVER
      601 IRTLHNGYLA GCGVTTPRLD NIPRTVDFAL EMRRIVDRFN CQTGNDLHLR VGINTGDVIS
      661 GLVGRSSVVY DMWGAAVSLA YQMHSGSPQP GIYVTSQVYE AMRDVWQFTA AGTISVGGLE
      721 EPIYRLSERS
//