LOCUS       SIU01062.1               230 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSPOSASE [SECOND PART] protein.
ACCESSION   LT708304-2476
PROTEIN_ID  SIU01062.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2447C"
                     /note="Mb2447c, -, len: 230 aa. Equivalent to 3' end of
                     Rv2424c, len: 333 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (98.7% identity in 230 aa overlap). Probable
                     transposase for IS1558, similar to IS element proteins
                     e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium
                     tuberculosis (221 aa), FASTA scores: opt: 1491, E():
                     6.2e-87, (98.6% identity in 221 aa overlap);
                     P19780|YIS1_STRCO HYPOTHETICAL INSERTION ELEMENT IS110
                     from Streptomyces coelicolor (45 aa), FASTA scores: opt:
                     203, E(): 1.7e-05; (27.3% identity in 238 aa overlap);
                     etc. Contains PS01159 WW/rsp5/WWP domain signature.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv2424c exists as a single
                     gene. In Mycobacterium bovis, a frameshift due to a 2 bp
                     deletion (gt-*) splits Rv2424c into 2 parts, Mb2447c and
                     Mb2448c. Mb2447c found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
                     /db_xref="GOA:A0A1R3Y171"
                     /db_xref="InterPro:IPR003346"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y171"
BEGIN
        1 MLADLARGSM RSKIPDLQRA LEGRFDDHHA LMCRLHLAHL DQLDAMIGAL DEQIEQLMHP
       61 FCARRELIAS IPGIGVGASA TVISEIGADP AAWFPSAEHL ASWVRLCPGN HESAGKRHHG
      121 ARRTGNQHLQ PVLVECAWAA VRTDGYLREY YRRQVRKFGG FRSPAANKKA IIAVAHKLIV
      181 IIWHVLATGR PYQDLGADYF TTRMDPDKER RRLVAKLEAQ GLGVTLEPAA
//