LOCUS SIU01062.1 230 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE TRANSPOSASE [SECOND PART] protein. ACCESSION LT708304-2476 PROTEIN_ID SIU01062.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2447C" /note="Mb2447c, -, len: 230 aa. Equivalent to 3' end of Rv2424c, len: 333 aa, from Mycobacterium tuberculosis strain H37Rv, (98.7% identity in 230 aa overlap). Probable transposase for IS1558, similar to IS element proteins e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 1491, E(): 6.2e-87, (98.6% identity in 221 aa overlap); P19780|YIS1_STRCO HYPOTHETICAL INSERTION ELEMENT IS110 from Streptomyces coelicolor (45 aa), FASTA scores: opt: 203, E(): 1.7e-05; (27.3% identity in 238 aa overlap); etc. Contains PS01159 WW/rsp5/WWP domain signature. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2424c exists as a single gene. In Mycobacterium bovis, a frameshift due to a 2 bp deletion (gt-*) splits Rv2424c into 2 parts, Mb2447c and Mb2448c. Mb2447c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y171" /db_xref="InterPro:IPR003346" /db_xref="UniProtKB/TrEMBL:A0A1R3Y171" BEGIN 1 MLADLARGSM RSKIPDLQRA LEGRFDDHHA LMCRLHLAHL DQLDAMIGAL DEQIEQLMHP 61 FCARRELIAS IPGIGVGASA TVISEIGADP AAWFPSAEHL ASWVRLCPGN HESAGKRHHG 121 ARRTGNQHLQ PVLVECAWAA VRTDGYLREY YRRQVRKFGG FRSPAANKKA IIAVAHKLIV 181 IIWHVLATGR PYQDLGADYF TTRMDPDKER RRLVAKLEAQ GLGVTLEPAA //