LOCUS SIU01059.1 211 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO- NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NICOTINATE MONONUCLEOTIDE ADENYLYLTRANSFERASE) (NAMN ADENYLYLTRANSFERASE) protein. ACCESSION LT708304-2473 PROTEIN_ID SIU01059.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="nadD" /locus_tag="BQ2027_MB2444C" /note="Mb2444c, nadD, len: 211 aa. Equivalent to Rv2421c, len: 211 aa, from Mycobacterium tuberculosis strain H37Rv, (99.5% identity in 211 aa overlap). Probable nadD, nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18), equivalent to Q9CBZ8|NADD_MYCLE|ML1454 PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE from Mycobacterium leprae (214 aa), FASTA scores: opt: 1125, E(): 2.7e-66, (80.2% identity in 212 aa overlap). Also highly similar to Q9RDK7|NADD_STRCO PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE from Streptomyces coelicolor (188 aa), FASTA scores: opt: 855, E(): 9.8e-49, (66.5% identity in 194 aa overlap); and similar to others e.g. P54455|NADD_BACSU from Bacillus subtilis (189 aa), FASTA scores: opt: 351, E(): 7e-16, (36.1% identity in 191 aa overlap); etc. BELONGS TO THE NADD FAMILY. Protein product from Mb2444c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2444c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:Q7TYM1" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="UniProtKB/Swiss-Prot:Q7TYM1" BEGIN 1 MGGTFDPIHY GHLVAASEVA DLFDLDEVVF VPSGQPWQKG RQVSAAEHRY LMTVIATASN 61 PRFSVSRVDI DRGGPTYTKD TLADLHALHP DSELYFTTGA DALASIMSWQ GWEELFELAR 121 FVGVSRPGYE LRNEHITSLL GQLAKDALTL VEIPALAISS TDCRQRAEQS RPLWYLMPDS 181 VVQYVSKCRL YCGACDAGAR STTSLAAGNG L //