LOCUS       SIU01059.1               211 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-
            NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE)
            (NICOTINATE MONONUCLEOTIDE ADENYLYLTRANSFERASE) (NAMN
            ADENYLYLTRANSFERASE) protein.
ACCESSION   LT708304-2473
PROTEIN_ID  SIU01059.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="nadD"
                     /locus_tag="BQ2027_MB2444C"
                     /note="Mb2444c, nadD, len: 211 aa. Equivalent to Rv2421c,
                     len: 211 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 211 aa overlap). Probable nadD,
                     nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18),
                     equivalent to Q9CBZ8|NADD_MYCLE|ML1454 PROBABLE
                     NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE from
                     Mycobacterium leprae (214 aa), FASTA scores: opt: 1125,
                     E(): 2.7e-66, (80.2% identity in 212 aa overlap). Also
                     highly similar to Q9RDK7|NADD_STRCO PROBABLE
                     NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE from
                     Streptomyces coelicolor (188 aa), FASTA scores: opt: 855,
                     E(): 9.8e-49, (66.5% identity in 194 aa overlap); and
                     similar to others e.g. P54455|NADD_BACSU from Bacillus
                     subtilis (189 aa), FASTA scores: opt: 351, E(): 7e-16,
                     (36.1% identity in 191 aa overlap); etc. BELONGS TO THE
                     NADD FAMILY. Protein product from Mb2444c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb2444c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:Q7TYM1"
                     /db_xref="InterPro:IPR004821"
                     /db_xref="InterPro:IPR005248"
                     /db_xref="InterPro:IPR014729"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TYM1"
BEGIN
        1 MGGTFDPIHY GHLVAASEVA DLFDLDEVVF VPSGQPWQKG RQVSAAEHRY LMTVIATASN
       61 PRFSVSRVDI DRGGPTYTKD TLADLHALHP DSELYFTTGA DALASIMSWQ GWEELFELAR
      121 FVGVSRPGYE LRNEHITSLL GQLAKDALTL VEIPALAISS TDCRQRAEQS RPLWYLMPDS
      181 VVQYVSKCRL YCGACDAGAR STTSLAAGNG L
//