LOCUS SIU01052.1 523 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 DNA internalization-related competence protein ComEC/Rec2 protein. ACCESSION LT708304-2466 PROTEIN_ID SIU01052.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2437C" /note="Mb2437c, -, len: 523 aa. Similar to Rv2414c, len: 514 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 483 aa overlap). Conserved hypothetical protein, showing some similarity with COME OPERON PROTEINS 3 (COMEC OR COME3) e.g. Q9RTB1|DR1854 PUTATIVE COMPETENCE PROTEIN COMEC/REC2 from Deinococcus radiodurans (755 aa), FASTA scores: opt: 311, E(): 8.2e-11, (27.3% identity in 538 aa overlap); P73100|COME|SLL1929 COME PROTEIN from Synechocystis sp. strain PCC 6803 (709 aa), FASTA scores: opt: 302, E(): 2.6e-10, (26.3% identity in 323 aa overlap) (no similarity on N-terminus); P39695|CME3_BACSU COME OPERON PROTEIN 3 from Bacillus subtilis (776 aa), FASTA scores: opt: 273, E(): 1.4e-08, (25.2% identity in 282 aa overlap) (no similarity on N-terminus); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a single base insertion (*-t) leads to a longer product with a different COOH part compared to its homolog in Mycobacterium tuberculosis H37Rv (523 aa versus 514 aa). Mb2437c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y162" /db_xref="InterPro:IPR004477" /db_xref="UniProtKB/TrEMBL:A0A1R3Y162" BEGIN 1 MGFGASRLDV RLVPAALVSW IVTAAGIVWP IGNVCALCCV VVALGGGALW WCVARRSWHA 61 PRLGSISAGL VAVGMVGAGY GLAVALRSEA VDRHPITVAF GTSALVTVTP SESPVSLGRG 121 RLMFRATVQR LRDDETSGRV VVFARALDFG ELMVGQPVQF RARISRPARH DLTVAVFNAT 181 GRPTVGRAGP VHRAAHIVRH RFAAAVREVL PADQATMLPA LVLGDTSTVT ALTSREFRAA 241 GLTHLTAVSG ANVTIVCAAA LVSARLIGPR AAVVCAAVAL VAFVILVQPT ASVLRAAVMG 301 AIALVGMLSA RRRQAIPALS GSVLVLLAAA PHLAVDIGFA LSVAATGALV VIAPVWSRRL 361 VDRGCPKVLA DALAVAAAAQ LVTAPLVAAI SGRVSLVAVV ANLAVAAVIA PITVLGSVAA 421 VLVVPWPAGA QVLIRFTGPE VWWVLRVAHW ASGVPAATVP VAAGLPGVLL VGGATVFTVA 481 QWRLALVSRG HVQNDGGGRH MSACLVAVRA GRPFVTPSWG ERG //