LOCUS       SIU01052.1               523 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 DNA
            internalization-related competence protein ComEC/Rec2
            protein.
ACCESSION   LT708304-2466
PROTEIN_ID  SIU01052.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2437C"
                     /note="Mb2437c, -, len: 523 aa. Similar to Rv2414c, len:
                     514 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 483 aa overlap). Conserved
                     hypothetical protein, showing some similarity with COME
                     OPERON PROTEINS 3 (COMEC OR COME3) e.g. Q9RTB1|DR1854
                     PUTATIVE COMPETENCE PROTEIN COMEC/REC2 from Deinococcus
                     radiodurans (755 aa), FASTA scores: opt: 311, E():
                     8.2e-11, (27.3% identity in 538 aa overlap);
                     P73100|COME|SLL1929 COME PROTEIN from Synechocystis sp.
                     strain PCC 6803 (709 aa), FASTA scores: opt: 302, E():
                     2.6e-10, (26.3% identity in 323 aa overlap) (no similarity
                     on N-terminus); P39695|CME3_BACSU COME OPERON PROTEIN 3
                     from Bacillus subtilis (776 aa), FASTA scores: opt: 273,
                     E(): 1.4e-08, (25.2% identity in 282 aa overlap) (no
                     similarity on N-terminus); etc.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     single base insertion (*-t) leads to a longer product with
                     a different COOH part compared to its homolog in
                     Mycobacterium tuberculosis H37Rv (523 aa versus 514 aa).
                     Mb2437c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y162"
                     /db_xref="InterPro:IPR004477"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y162"
BEGIN
        1 MGFGASRLDV RLVPAALVSW IVTAAGIVWP IGNVCALCCV VVALGGGALW WCVARRSWHA
       61 PRLGSISAGL VAVGMVGAGY GLAVALRSEA VDRHPITVAF GTSALVTVTP SESPVSLGRG
      121 RLMFRATVQR LRDDETSGRV VVFARALDFG ELMVGQPVQF RARISRPARH DLTVAVFNAT
      181 GRPTVGRAGP VHRAAHIVRH RFAAAVREVL PADQATMLPA LVLGDTSTVT ALTSREFRAA
      241 GLTHLTAVSG ANVTIVCAAA LVSARLIGPR AAVVCAAVAL VAFVILVQPT ASVLRAAVMG
      301 AIALVGMLSA RRRQAIPALS GSVLVLLAAA PHLAVDIGFA LSVAATGALV VIAPVWSRRL
      361 VDRGCPKVLA DALAVAAAAQ LVTAPLVAAI SGRVSLVAVV ANLAVAAVIA PITVLGSVAA
      421 VLVVPWPAGA QVLIRFTGPE VWWVLRVAHW ASGVPAATVP VAAGLPGVLL VGGATVFTVA
      481 QWRLALVSRG HVQNDGGGRH MSACLVAVRA GRPFVTPSWG ERG
//