LOCUS SIU01045.1 280 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 MBL-
fold metallo-hydrolase superfamily protein.
ACCESSION LT708304-2459
PROTEIN_ID SIU01045.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="rnz"
/locus_tag="BQ2027_MB2430"
/note="Mb2430, -, len: 280 aa. Equivalent to Rv2407, len:
273 aa, from Mycobacterium tuberculosis strain H37Rv,
(97.5% identity in 280 aa overlap). Conserved hypothetical
protein, highly similar (but longer at N-terminus) to
AAK46775|MT2479 putative arylsulfatase from Mycobacterium
tuberculosis strain CDC1551 (224 aa) FASTA scores: opt:
1433, E(): 2.5e-81, (96.43% identity in 224 aa overlap);
O33130|MLCL536.01 HYPOTHETICAL PROTEIN from Mycobacterium
leprae (220 aa), FASTA scores: opt: 658, E(): 1.5e-33,
(56.75% identity in 215 aa overlap). Also similar to
AAK23160|CC1176 Metallo-beta-lactamase family protein from
Caulobacter crescentus (317 aa), FASTA scores: opt: 286,
E(): 1.8e-10, (33% identity in 291 aa overlap). And
similar to other hypothetical proteins eg
Q49744|B1937_C1_163 HYPOTHETICAL 22.6 KDA PROTEIN
(PRECURSOR) from Mycobacterium leprae (211 aa), FASTA
scores: opt: 623, E(): 2.1e-31, (56.3% identity in 206 aa
overlap); O27859|MTH1831 CONSERVED PROTEIN from
Methanothermobacter thermautotrophicus (307 aa), FASTA
scores: opt: 268, E(): 2.3e-09, (28.35% identity in 307 aa
overlap); etc. REMARK-M.bovis-M.tuberculosis: In
Mycobacterium bovis, a 21 bp in-frame insertion leads to a
longer product compared to its homolog in Mycobacterium
tuberculosis strain H37Rv (280 aa versus 273 aa). Protein
product from Mb2430 detected using shotgun mass
spectrometry and SWATH mass spectrometry. Mb2430 found to
be expressed during exponential growth in Sauton's minimal
media by RNA-sequencing."
/db_xref="GOA:Q7TYN1"
/db_xref="InterPro:IPR001279"
/db_xref="InterPro:IPR013471"
/db_xref="InterPro:IPR036866"
/db_xref="UniProtKB/Swiss-Prot:Q7TYN1"
BEGIN
1 MLEITLLGTG SPIPDPDRAG PSTLVRAGAQ AFLVDCGRGV LQRAAAVGVG AAGLSAVLLT
61 HLHSDHIAEL GDVLITSWVT NFAADPAPLP IIGPPGTAEV VEATLKAFGH DIGYRIAHHA
121 DLTTPPPIEV HEYTAGPAWD RDGVTIRVAP TDHRPVTPTI GFRIESDGAS VVLAGDTVPC
181 DSLDQLAAGA DALVHTVIRK DIVTQIPQQR VKDICDYHSS VQEAAATANR AGVGTLVMTH
241 YVPAIGPGQE EQWRALAATE FSGRIEVGND LHRVEVHPRR
//