LOCUS       SIU01042.1               653 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            GTP-BINDING PROTEIN LEPA (GTP-BINDING ELONGATION FACTOR)
            protein.
ACCESSION   LT708304-2456
PROTEIN_ID  SIU01042.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="lepA"
                     /locus_tag="BQ2027_MB2427C"
                     /note="Mb2427c, lepA, len: 653 aa. Equivalent to Rv2404c,
                     len: 653 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 653 aa overlap). Probable lepA,
                     GTP-binding protein (a protein of unknown function, but
                     apparently with membrane-related functions and very
                     similar to protein synthesis elongation factors; see
                     citations below). Equivalent to
                     P53530|LEPA_MYCLE|ML0611|B1937_F3_81 GTP-BINDING PROTEIN
                     from Mycobacterium leprae (646 aa), FASTA scores: opt:
                     3610, E(): 1.2e-205, (88.0% identity in 649 aa overlap).
                     Also highly similar to many GTP-BINDING PROTEINS LEPA e.g.
                     Q9RDC9|LEPA_STRCO|SCC77.29c from Streptomyces coelicolor
                     (622 aa), FASTA scores: opt: 3046, E(): 2.3e-172, (74.3%
                     identity in 626 aa overlap); P37949|LEPA_BACSU from B.
                     subtilis (612 aa), FASTA scores: opt: 2430, E(): 5.3e-136,
                     (58.7% identity in 610 aa overlap); etc. Contains PS00017
                     ATP/GTP-binding site motif A (P-loop), and PS00301
                     GTP-binding elongation factors signature. BELONGS TO THE
                     GTP-BINDING ELONGATION FACTOR FAMILY, LEPA SUBFAMILY.
                     Protein product from Mb2427c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb2427c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P65270"
                     /db_xref="InterPro:IPR000640"
                     /db_xref="InterPro:IPR000795"
                     /db_xref="InterPro:IPR005225"
                     /db_xref="InterPro:IPR006297"
                     /db_xref="InterPro:IPR009000"
                     /db_xref="InterPro:IPR013842"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR031157"
                     /db_xref="InterPro:IPR035647"
                     /db_xref="InterPro:IPR035654"
                     /db_xref="InterPro:IPR038363"
                     /db_xref="UniProtKB/Swiss-Prot:P65270"
BEGIN
        1 MRTPCSQHRR DRPSAIGSQL PDADTLDTRQ PPLQEIPISS FADKTFTAPA QIRNFCIIAH
       61 IDHGKSTLAD RMLQLTGVVD ERSMRAQYLD RMDIERERGI TIKAQNVRLP WRVDKTDYVL
      121 HLIDTPGHVD FTYEVSRALE ACEGAVLLVD AAQGIEAQTL ANLYLALDRD LHIIPVLNKI
      181 DLPAADPDRY AAEMAHIIGC EPAEVLRVSG KTGEGVSDLL DEVVRQVPPP QGDAEAPTRA
      241 MIFDSVYDIY RGVVTYVRVV DGKISPRERI MMMSTGATHE LLEVGIVSPE PKPCEGLGVG
      301 EVGYLITGVK DVRQSKVGDT VTSLSRARGA AAEALTGYRE PKPMVYSGLY PVDGSDYPNL
      361 RDALDKLQLN DAALTYEPET SVALGFGFRC GFLGLLHMEI TRERLEREFG LDLISTSPNV
      421 VYRVHKDDGT EIRVTNPSDW PEGKIRTVYE PVVKTTIIAP SEFIGTIMEL CQSRRGELGG
      481 MDYLSPERVE LRYTMPLGEI IFDFFDALKS RTRGYASLDY EEAGEQEAAL VKVDILLQGE
      541 AVDAFSAIVH KDTAYAYGNK MTTKLKELIP RQQFEVPVQA AIGSKIIARE NIRAIRKDVL
      601 SKCYGGDITR KRKLLEKQKE GKKRMKTIGR VEVPQEAFVA ALSTDAAGDK GKK
//