LOCUS SIU01041.1 251 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CONSERVED LIPOPROTEIN LPPR protein. ACCESSION LT708304-2455 PROTEIN_ID SIU01041.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="lppR" /locus_tag="BQ2027_MB2426C" /note="Mb2426c, lppR, len: 251 aa. Equivalent to Rv2403c, len: 251 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 251 aa overlap). Probable lppR, conserved lipoprotein, with weak similarity with MYCOBACTERIAL SERINE/THREONINE PROTEIN KINASES (EC 2.7.1.-) e.g. AAK45563|MT1304 from Mycobacterium tuberculosis strain CDC1551 (626 aa), FASTA scores: opt: 186, E(): 0.00023, (24.4% identity in 238 aa overlap), and the C-terminal part of Q11053|Rv1266c|MTCY50.16|PKNH_MYCTU from Mycobacterium tuberculosis (626 aa), FASTA scores: opt: 185, E()= 0.00027, (24.35% identity in 238 aa overlap). Has signal peptide and appropriate positioned prokaryotic lipoprotein attachment site (PS00013). Could belong to the SER/THR FAMILY of protein kinases. Protein product from Mb2426c detected using SWATH mass spectrometry. Mb2426c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR026954" /db_xref="InterPro:IPR038232" /db_xref="UniProtKB/TrEMBL:A0A1R3Y147" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MTNRWRWVVP LFAVFLAAGC TTTTTGKAGL APNAVPRPLM GSLIQRVPLD GAALSTLLNQ 61 PFQALPPFPP VFGGSDSLGD SDVSARPADC VGVGYLTQRN VYRSVEVKSV ARVSWRHDGS 121 SVKVDDLDEG VVALPSAAAA DDLFARFSAQ WKECDGTTLT VPASAFGQRS ITDVRVADSV 181 VAATVSLRRG THSILASVPQ ARAVGVRGNC VVEVAVTFFG ITHPSDQGSA DISTSAVDIA 241 HAMMDRISEL S //