LOCUS       SIU01041.1               251 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED LIPOPROTEIN LPPR protein.
ACCESSION   LT708304-2455
PROTEIN_ID  SIU01041.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="lppR"
                     /locus_tag="BQ2027_MB2426C"
                     /note="Mb2426c, lppR, len: 251 aa. Equivalent to Rv2403c,
                     len: 251 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 251 aa overlap). Probable lppR,
                     conserved lipoprotein, with weak similarity with
                     MYCOBACTERIAL SERINE/THREONINE PROTEIN KINASES (EC
                     2.7.1.-) e.g. AAK45563|MT1304 from Mycobacterium
                     tuberculosis strain CDC1551 (626 aa), FASTA scores: opt:
                     186, E(): 0.00023, (24.4% identity in 238 aa overlap), and
                     the C-terminal part of Q11053|Rv1266c|MTCY50.16|PKNH_MYCTU
                     from Mycobacterium tuberculosis (626 aa), FASTA scores:
                     opt: 185, E()= 0.00027, (24.35% identity in 238 aa
                     overlap). Has signal peptide and appropriate positioned
                     prokaryotic lipoprotein attachment site (PS00013). Could
                     belong to the SER/THR FAMILY of protein kinases. Protein
                     product from Mb2426c detected using SWATH mass
                     spectrometry. Mb2426c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR026954"
                     /db_xref="InterPro:IPR038232"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y147"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTNRWRWVVP LFAVFLAAGC TTTTTGKAGL APNAVPRPLM GSLIQRVPLD GAALSTLLNQ
       61 PFQALPPFPP VFGGSDSLGD SDVSARPADC VGVGYLTQRN VYRSVEVKSV ARVSWRHDGS
      121 SVKVDDLDEG VVALPSAAAA DDLFARFSAQ WKECDGTTLT VPASAFGQRS ITDVRVADSV
      181 VAATVSLRRG THSILASVPQ ARAVGVRGNC VVEVAVTFFG ITHPSDQGSA DISTSAVDIA
      241 HAMMDRISEL S
//