LOCUS       SIU01036.1               283 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER
            CYST protein.
ACCESSION   LT708304-2450
PROTEIN_ID  SIU01036.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cysT"
                     /locus_tag="BQ2027_MB2421C"
                     /note="Mb2421c, cysT, len: 283 aa. Equivalent to Rv2399c,
                     len: 283 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 283 aa overlap). Probable cysT,
                     sulfate-transport integral membrane protein ABC
                     transporter (see citations below), similar to others e.g.
                     BAB48989|MLR1667 PERMEASE PROTEIN OF SULFATE ABC
                     TRANSPORTER from Rhizobium loti (283 aa), FASTA scores:
                     opt: 756, E(): 7.9e-40, (40.95% identity in 271 aa
                     overlap); Q9K878|CYST|BH3128 SULFATE ABC TRANSPORTER
                     (PERMEASE) from Bacillus halodurans (279 aa), FASTA
                     scores: opt: 750, E(): 1.8e-39, (44.55% identity in 258 aa
                     overlap); P16701|CYST_ECOLI|CYSU|CYST|B2424 from
                     Escherichia coli (277 aa), FASTA scores: opt: 669, E():
                     1.9e-34, (40.0% identity in 260 aa overlap); etc. Contains
                     PS00402 Binding-protein-dependent transport systems inner
                     membrane component signature, and PS00017 ATP/GTP-binding
                     site motif A (P-loop). BELONGS TO THE CYSTW SUBFAMILY.
                     Protein product from Mb2421c detected using shotgun mass
                     spectrometry. Mb2421c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1B0"
                     /db_xref="InterPro:IPR000515"
                     /db_xref="InterPro:IPR005667"
                     /db_xref="InterPro:IPR011865"
                     /db_xref="InterPro:IPR035906"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1B0"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTESLVGERR APQFRARLSG PAGPPSVRVG MAVVWLSVIV LLPLAAIVWQ AAGGGWRAFW
       61 LAVSSHAAME SFRVTLTIST AVTVINLVFG LLIAWVLVRD DFAGKRIVDA IIDLPFALPT
      121 IVASLVMLAL YGNNSPVGLH FQHTATGVGV ALAFVTLPFV VRAVQPVLLE IDRETEEAAA
      181 SLGANGAKIF TSVVLPSLTP ALLSGAGLAF SRAIGEFGSV VLIGGAVPGK TEVSSQWIRT
      241 LIENDDRTGA AAISVVLLSI SFIVLLILRV VGARAAKREE MAA
//