LOCUS SIU01036.1 283 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER CYST protein. ACCESSION LT708304-2450 PROTEIN_ID SIU01036.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="cysT" /locus_tag="BQ2027_MB2421C" /note="Mb2421c, cysT, len: 283 aa. Equivalent to Rv2399c, len: 283 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 283 aa overlap). Probable cysT, sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. BAB48989|MLR1667 PERMEASE PROTEIN OF SULFATE ABC TRANSPORTER from Rhizobium loti (283 aa), FASTA scores: opt: 756, E(): 7.9e-40, (40.95% identity in 271 aa overlap); Q9K878|CYST|BH3128 SULFATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (279 aa), FASTA scores: opt: 750, E(): 1.8e-39, (44.55% identity in 258 aa overlap); P16701|CYST_ECOLI|CYSU|CYST|B2424 from Escherichia coli (277 aa), FASTA scores: opt: 669, E(): 1.9e-34, (40.0% identity in 260 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature, and PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE CYSTW SUBFAMILY. Protein product from Mb2421c detected using shotgun mass spectrometry. Mb2421c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y1B0" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005667" /db_xref="InterPro:IPR011865" /db_xref="InterPro:IPR035906" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1B0" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MTESLVGERR APQFRARLSG PAGPPSVRVG MAVVWLSVIV LLPLAAIVWQ AAGGGWRAFW 61 LAVSSHAAME SFRVTLTIST AVTVINLVFG LLIAWVLVRD DFAGKRIVDA IIDLPFALPT 121 IVASLVMLAL YGNNSPVGLH FQHTATGVGV ALAFVTLPFV VRAVQPVLLE IDRETEEAAA 181 SLGANGAKIF TSVVLPSLTP ALLSGAGLAF SRAIGEFGSV VLIGGAVPGK TEVSSQWIRT 241 LIENDDRTGA AAISVVLLSI SFIVLLILRV VGARAAKREE MAA //