LOCUS SIU01035.1 272 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER CYSW protein. ACCESSION LT708304-2449 PROTEIN_ID SIU01035.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="cysW" /locus_tag="BQ2027_MB2420C" /note="Mb2420c, cysW, len: 272 aa. Equivalent to Rv2398c, len: 272 aa, from Mycobacterium tuberculosis strain H37Rv, (99.3% identity in 272 aa overlap). Probable cysW, sulfate-transport integral membrane protein ABC transporter (see citations below), similar to others e.g. Q9K877|CYSW|BH3129 SULFATE ABC TRANSPORTER (PERMEASE) from Bacillus halodurans (287 aa), FASTA scores: opt: 765, E(): 4.1e-40, (43.8% identity in 249 aa overlap); P27370|CYSW_SYNP7 sulfate transport system (permease) protein from Synechococcus sp. strain PCC 7942 (Anacystis nidulans R2) (286 aa), FASTA scores: opt: 757, E(): 1.3e-39, (44.3% identity in 264 aa overlap); Q9I6K9|CYSW|PA0281 SULFATE TRANSPORT PROTEIN from Pseudomonas aeruginosa (289 aa), FASTA scores: opt: 753, E(): 2.3e-39, (44.4% identity in 250 aa overlap); P16702|P76534|CYSW_ECOLI SULFATE TRANSPORT SYSTEM PERMEASE from Escherichia coli (291 aa), FASTA scores: opt: 633, E(): 5.7e-32, (38.2% identity in 267 aa overlap); etc. Contains PS00402 Binding-protein-dependent transport systems inner membrane component signature. SIMILARITY WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS and BELONGS TO THE CYSTW SUBFAMILY. Mb2420c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y1W5" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005667" /db_xref="InterPro:IPR011866" /db_xref="InterPro:IPR035906" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1W5" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MTSLPAARYL VRSVALGYVF VLLIVPVALI LWRTFEPGFG QFYAWISTPA AISALNLSLL 61 VVAIVVPLNV IFGVTTALVL ARNRFRGKGV LQAIIDLPFA VSPVIVGVSL ILLWGSAGAL 121 GFVEQDLGFK IIFGLPGIVL ASMFVTCPFV VREVEPVLHE LGTDQEQAAA TLGSGWWQTF 181 WRITLPSIRW GLTYGIVLTV ARTLGEYGAV IIVSSNLPGT SQTLTLLVSD RYHRGAEYGA 241 YALSTLLMAV SVVVLIVQMV LDAHRARAVS EG //