LOCUS       SIU01035.1               272 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SULFATE-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER
            CYSW protein.
ACCESSION   LT708304-2449
PROTEIN_ID  SIU01035.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cysW"
                     /locus_tag="BQ2027_MB2420C"
                     /note="Mb2420c, cysW, len: 272 aa. Equivalent to Rv2398c,
                     len: 272 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.3% identity in 272 aa overlap). Probable cysW,
                     sulfate-transport integral membrane protein ABC
                     transporter (see citations below), similar to others e.g.
                     Q9K877|CYSW|BH3129 SULFATE ABC TRANSPORTER (PERMEASE) from
                     Bacillus halodurans (287 aa), FASTA scores: opt: 765, E():
                     4.1e-40, (43.8% identity in 249 aa overlap);
                     P27370|CYSW_SYNP7 sulfate transport system (permease)
                     protein from Synechococcus sp. strain PCC 7942 (Anacystis
                     nidulans R2) (286 aa), FASTA scores: opt: 757, E():
                     1.3e-39, (44.3% identity in 264 aa overlap);
                     Q9I6K9|CYSW|PA0281 SULFATE TRANSPORT PROTEIN from
                     Pseudomonas aeruginosa (289 aa), FASTA scores: opt: 753,
                     E(): 2.3e-39, (44.4% identity in 250 aa overlap);
                     P16702|P76534|CYSW_ECOLI SULFATE TRANSPORT SYSTEM PERMEASE
                     from Escherichia coli (291 aa), FASTA scores: opt: 633,
                     E(): 5.7e-32, (38.2% identity in 267 aa overlap); etc.
                     Contains PS00402 Binding-protein-dependent transport
                     systems inner membrane component signature. SIMILARITY
                     WITH INTEGRAL MEMBRANE COMPONENTS OF OTHER
                     BINDING-PROTEIN-DEPENDENT TRANSPORT SYSTEMS and BELONGS TO
                     THE CYSTW SUBFAMILY. Mb2420c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1W5"
                     /db_xref="InterPro:IPR000515"
                     /db_xref="InterPro:IPR005667"
                     /db_xref="InterPro:IPR011866"
                     /db_xref="InterPro:IPR035906"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1W5"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTSLPAARYL VRSVALGYVF VLLIVPVALI LWRTFEPGFG QFYAWISTPA AISALNLSLL
       61 VVAIVVPLNV IFGVTTALVL ARNRFRGKGV LQAIIDLPFA VSPVIVGVSL ILLWGSAGAL
      121 GFVEQDLGFK IIFGLPGIVL ASMFVTCPFV VREVEPVLHE LGTDQEQAAA TLGSGWWQTF
      181 WRITLPSIRW GLTYGIVLTV ARTLGEYGAV IIVSSNLPGT SQTLTLLVSD RYHRGAEYGA
      241 YALSTLLMAV SVVVLIVQMV LDAHRARAVS EG
//