LOCUS       SIU01030.1               516 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED INTEGRAL MEMBRANE PROTEIN [SECOND PART] protein.
ACCESSION   LT708304-2444
PROTEIN_ID  SIU01030.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2417"
                     /note="Mb2417, -, len: 516 aa. Equivalent to 3' end of
                     Rv2395, len: 667 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.8% identity in 516 aa overlap). Probable
                     conserved integral membrane protein, similar to
                     AAK24613|CC2646 OLIGOPEPTIDE TRANSPORTER/OPT FAMILY
                     PROTEIN from Caulobacter crescentus (666 aa), FASTA
                     scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa
                     overlap); Q9PIS5|CJ0204 PUTATIVE INTEGRAL MEMBRANE PROTEIN
                     from Campylobacter jejuni (665 aa), FASTA scores: opt:
                     1484, E(): 2.9e-77, (40.6% identity in 658 aa overlap);
                     and P44016|Y561_HAEIN hypothetical integral membrane
                     protein from Haemophilus influenzae (635 aa), FASTA
                     scores: opt: 1449, E(): 2.8e-75, (42.15% identity in 624
                     aa overlap). REMARK-M.bovis-M.tuberculosis: In
                     Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as
                     a single gene. In Mycobacterium bovis, a frameshift due to
                     a single base insertion (*-t) splits Rv2395 into 2 parts,
                     Mb2416 and Mb2417. Mb2417 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y129"
                     /db_xref="InterPro:IPR004813"
                     /db_xref="InterPro:IPR004814"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y129"
BEGIN
        1 MEHNRRGIGV IALGAAAAAG YALLASLRVI NNSLSATFRV GSGATMIGAS LSLALIGVGH
       61 LVGVTVGVAM IVGLAIAFGV MLPIRTAGQL PPDGDYAVAV ARIFSTDVRF IGAGAIAVAA
      121 AWTFLKILGP ILRGIADAAV SARTRRRGQA VGQTERDIPI HIVAMVVLLS LIPIGWLLAD
      181 FTDGTPLDDR RPGAIAAGVL LVLVIGLMVA AVCGYMAGLI GSSNSPISGV GILVVVLAGL
      241 LIKTAYGPAT GSQIPALVAY TVFTAALVFG VATISNDNLQ DLKTGQLVGA TPWKQQVALI
      301 IGVLVGSVVM APILQLMQAG FGFQGAPGAT ANALAAPQAA LMSALAKGVF GGSLNWSLVG
      361 VGALTGVIAV ALDETLAKTT TNLRLPPLAV GMGMYLPAAL TLMIPIGAFL GRIYDSWARW
      421 SGDDDERKKR LGVMLATGLI VGESLYGVLF AVIVATTGKE EPLAMVGDGF RFASQPLGAI
      481 VFAGLLAWLY QRTRVTASYR LAAPAGSSKP LPDLPG
//