LOCUS SIU01030.1 516 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CONSERVED INTEGRAL MEMBRANE PROTEIN [SECOND PART] protein. ACCESSION LT708304-2444 PROTEIN_ID SIU01030.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2417" /note="Mb2417, -, len: 516 aa. Equivalent to 3' end of Rv2395, len: 667 aa, from Mycobacterium tuberculosis strain H37Rv, (99.8% identity in 516 aa overlap). Probable conserved integral membrane protein, similar to AAK24613|CC2646 OLIGOPEPTIDE TRANSPORTER/OPT FAMILY PROTEIN from Caulobacter crescentus (666 aa), FASTA scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa overlap); Q9PIS5|CJ0204 PUTATIVE INTEGRAL MEMBRANE PROTEIN from Campylobacter jejuni (665 aa), FASTA scores: opt: 1484, E(): 2.9e-77, (40.6% identity in 658 aa overlap); and P44016|Y561_HAEIN hypothetical integral membrane protein from Haemophilus influenzae (635 aa), FASTA scores: opt: 1449, E(): 2.8e-75, (42.15% identity in 624 aa overlap). REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2395 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base insertion (*-t) splits Rv2395 into 2 parts, Mb2416 and Mb2417. Mb2417 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y129" /db_xref="InterPro:IPR004813" /db_xref="InterPro:IPR004814" /db_xref="UniProtKB/TrEMBL:A0A1R3Y129" BEGIN 1 MEHNRRGIGV IALGAAAAAG YALLASLRVI NNSLSATFRV GSGATMIGAS LSLALIGVGH 61 LVGVTVGVAM IVGLAIAFGV MLPIRTAGQL PPDGDYAVAV ARIFSTDVRF IGAGAIAVAA 121 AWTFLKILGP ILRGIADAAV SARTRRRGQA VGQTERDIPI HIVAMVVLLS LIPIGWLLAD 181 FTDGTPLDDR RPGAIAAGVL LVLVIGLMVA AVCGYMAGLI GSSNSPISGV GILVVVLAGL 241 LIKTAYGPAT GSQIPALVAY TVFTAALVFG VATISNDNLQ DLKTGQLVGA TPWKQQVALI 301 IGVLVGSVVM APILQLMQAG FGFQGAPGAT ANALAAPQAA LMSALAKGVF GGSLNWSLVG 361 VGALTGVIAV ALDETLAKTT TNLRLPPLAV GMGMYLPAAL TLMIPIGAFL GRIYDSWARW 421 SGDDDERKKR LGVMLATGLI VGESLYGVLF AVIVATTGKE EPLAMVGDGF RFASQPLGAI 481 VFAGLLAWLY QRTRVTASYR LAAPAGSSKP LPDLPG //