LOCUS SIU01016.1 1414 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PHENYLOXAZOLINE
SYNTHASE MBTB (PHENYLOXAZOLINE SYNTHETASE) protein.
ACCESSION LT708304-2430
PROTEIN_ID SIU01016.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/gene="mbtB"
/locus_tag="BQ2027_MB2404C"
/note="Mb2404c, mbtB, len: 1414 aa. Equivalent to Rv2383c,
len: 1414 aa, from Mycobacterium tuberculosis strain
H37Rv, (99.9% identity in 1414 aa overlap). mbtB,
phenyloxazoline synthase (see citations below), similar to
the N-terminal region of several synthetases e.g.
Q9EWP5|SC4C2.17 PUTATIVE NON-RIBOSOMAL PEPTIDE SYNTHASE
from Streptomyces coelicolor (2229 aa), FASTA scores: opt:
2878, E(): 4.1e-156, (46.85% identity in 1138 aa overlap);
Q9Z399|IRP2 YERSINIABACTIN BIOSYNTHETIC from Yersinia
pestis (2041 aa), FASTA scores: opt: 2297, E(): 5.3e-123,
(38.55% identity in 1069 aa overlap);
P48633|HMP2_YEREN|IRP2 HIGH-MOLECULAR-WEIGHT PROTEIN 2
(MAY BE INVOLVED IN THE NONRIBOSOMAL SYNTHESIS OF SMALL
PEPTIDES) from Yersinia enterocolitica (2035 aa), FASTA
scores: opt: 2275, E(): 9.4e-122, (38.45% identity in 1069
aa overlap); O85739|PCHE|PA4226 DIHYDROAERUGINOIC ACID
SYNTHETASE from Pseudomonas aeruginosa (1438 aa) FASTA
scores: opt: 2236, E(): 1.2e-119, (38.2% identity in 1330
aa overlap); Q9RFM8|PCHE PYOCHELIN SYNTHETASE from
Pseudomonas aeruginosa (1438 aa), FASTA scores: opt: 2229,
E(): 3e-119, (38.0% identity in 1329 aa overlap); etc.
Contains PS00455 Putative AMP-binding domain signature,
and PS00012 Phosphopantetheine attachment site. BELONGS TO
THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. Protein
product from Mb2404c detected using SWATH mass
spectrometry."
/db_xref="GOA:Q7TYQ4"
/db_xref="InterPro:IPR000873"
/db_xref="InterPro:IPR001031"
/db_xref="InterPro:IPR001242"
/db_xref="InterPro:IPR006162"
/db_xref="InterPro:IPR009081"
/db_xref="InterPro:IPR010071"
/db_xref="InterPro:IPR020806"
/db_xref="InterPro:IPR020845"
/db_xref="InterPro:IPR023213"
/db_xref="InterPro:IPR025110"
/db_xref="InterPro:IPR029058"
/db_xref="InterPro:IPR036736"
/db_xref="InterPro:IPR042099"
/db_xref="UniProtKB/Swiss-Prot:Q7TYQ4"
BEGIN
1 MVHATACSEI IRAEVAELLG VRADALHPGA NLVGQGLDSI RMMSLVGRWR RKGIAVDFAT
61 LAATPTIEAW SQLVSAGTGV APTAVAAPGD AGLSQEGEPF PLAPMQHAMW VGRHDHQQLG
121 GVAGHLYVEF DGARVDPDRL RAAATRLALR HPMLRVQFLP DGTQRIPPAA GSRDFPISVA
181 DLRHVAPDVV DQRLAGIRDA KSHQQLDGAV FELALTLLPG ERTRLHVDLD MQAADAMSYR
241 ILLADLAALY DGREPPALGY TYQEYRQAIE AEETLPQPVR DADRDWWAQR IPQLPDPPAL
301 PTRAGGERDR RRSTRRWHWL DPQTRDALFA RARARGITPA MTLAAAFANV LARWSASSRF
361 LLNLPLFSRQ ALHPDVDLLV GDFTSSLLLD VDLTGARTAA ARAQAVQEAL RSAAGHSAYP
421 GLSVLRDLSR HRGTQVLAPV VFTSALGLGD LFCPDVTEQF GTPGWIISQG PQVLLDAQVT
481 EFDGGVLVNW DVREGVFAPG VIDAMFTHQV DELLRLAAGD DAWDAPSPSA LPAAQRAVRA
541 ALNGRTAAPS TEALHDGFFR QAQQQPDAPA VFASSGDLSY AQLRDQASAV AAALRAAGLR
601 VGDTVAVLGP KTGEQVAAVL GILAAGGVYL PIGVDQPRDR AERILATGSV NLALVCGPPC
661 QVRVPVPTLL LADVLAAAPA EFVPGPSDPT ALAYVLFTSG STGEPKGVEV AHDAAMNTVE
721 TFIRHFELGA ADRWLALATL ECDMSVLDIF AALRSGGAIV VVDEAQRRDP DAWARLIDTY
781 EVTALNFMPG WLDMLLEVGG GRLSSLRAVA VGGDWVRPDL ARRLQVQAPS ARFAGLGGAT
841 ETAVHATIFE VQDAANLPPD WASVPYGVPF PNNACRVVAD SGDDCPDWVA GELWVSGRGI
901 ARGYRGRPEL TAERFVEHDG RTWYRTGDLA RYWHDGTLEF VGRADHRVKI SGYRVELGEI
961 EAALQRLPGV HAAAATVLPG GSDVLAAAVC VDDAGVTAES IRQQLADLVP AHMIPRHVTL
1021 LDRIPFTDSG KIDRAEVGAL LAAEVERSGD RSAPYAAPRT VLQRALRRIV ADILGRANDA
1081 VGVHDDFFAL GGDSVLATQV VAGIRRWLDS PSLMVADMFA ARTIAALAQL LTGREANADR
1141 LELVAEVYLE IANMTSADVM AALDPIEQPA QPAFKPWVKR FTGTDKPGAV LVFPHAGGAA
1201 AAYRWLAKSL VANDVDTFVV QYPQRADRRS HPAADSIEAL ALELFEAGDW HLTAPLTLFG
1261 HCMGAIVAFE FARLAERNGV PVRALWASSG QAPSTVAASG PLPTADRDVL ADMVDLGGTD
1321 PVLLEDEEFV ELLVPAVKAD YRALSGYSCP PDVRIRANIH AVGGNRDHRI SREMLTSWET
1381 HTSGRFTLSH FDGGHFYLND HLDAVARMVS ADVR
//