LOCUS       SIU00979.1               826 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL9A [FIRST
            PART] protein.
ACCESSION   LT708304-2393
PROTEIN_ID  SIU00979.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mmpL9a"
                     /locus_tag="BQ2027_MB2367"
                     /note="Mb2367, mmpL9a, len: 826 aa. Equivalent to 5' end
                     of Rv2339, len: 962 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.9% identity in 826 aa overlap). Probable
                     mmpL9, conserved transmembrane transport protein (see
                     citation below), with strong similarity to other
                     Mycobacterial proteins e.g. P54881|YV34_MYCLE|MML4_MYCLE
                     hypothetical 105.2 kd protein from Mycobacterium leprae
                     (959 aa), FASTA scores: opt: 3799, E(): 0, (59.3% identity
                     in 937 aa overlap); G699237|U1740AB from Mycobacterium
                     leprae; and MTCY20G9.34; MTCY48.08c; MTCY19G5.06 from M.
                     tuberculosis. BELONGS TO THE MMPL FAMILY.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, mmpL9 exists as a single gene.
                     In Mycobacterium bovis, truncation due to a single base
                     transition (g-a) splits mmpL9 into 2 parts, mmpL9a and
                     mmpL9b, resulting in a shorter mmpL9a product. Mb2367
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y0X6"
                     /db_xref="InterPro:IPR004869"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y0X6"
BEGIN
        1 MVPGEVHMSD TPSGPHPIIP RTIRLAAIPI LLCWLGFTVF VSVVVPPLEA IGETRAVAVA
       61 PDDAQSMRAM RRAGKVFNEF DSNSIAMVVL ESDQPLGEKA HRYYDHLVDT LVLDQSHIQH
      121 IQDFWRDPLT AAGAVSADGK AAYVQLYLAG NMGEALANES VEAVRKIVAN STPPEGIRTY
      181 VTGPAALFAD QIAAGDRSMK LITGLTFAVI TVLLLLVYRS IATTLLILPM VFIGLGATRG
      241 TIAFLGYHGM VGLSTFVVNI LTALAIAAGT DYAIFLVGRY QEARHIGQNR EASFYTMYRG
      301 TANVILGSGL TIAGATYCLS FARLTLFHTM GPPLAIGMLV SVAAALTLAP AIIAIAGRFG
      361 LLDPKRRLKT RGWRRVGTAV VRWPGPILAT SVALALVGLL ALPGYRPGYN DRYYLRAGTP
      421 VNRGYAAADR HFGPARMNPE MLLVESDQDM RNPAGMLVID KIAKEVLHVS GVERVQAITR
      481 PQGVPLEHAS IPFQISMMGA TQTMSLPYMR ERMADMLTMS DEMLVAINSM EQMLDLVQQL
      541 NDVTHEMAAT TREIKATTSE LRDHLADIDD FVRPLRSYFY WEHHCFDIPL CSATRSLFDT
      601 LDGVDTLTDQ LRALTDDMNK MEALTPQFLA LLPPMITTMK TMRTMMLTMR STISGVQDQM
      661 ADMQDHATAM GQAFDTAKSG DSFYLPPEAF DNAEFQQGMK LFLSPNGKAV RFVISHESDP
      721 ASTEGIDRIE AIRAATKDAI KATPLQGAKI YIGGTAATYQ DIRDGTKYDI LIVGIAAVCL
      781 VFIVMLMITQ SLIASLVIVG TVLLSLGTAF GLSVLIWQHF VGLQVH
//