LOCUS SIU00979.1 826 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL9A [FIRST PART] protein. ACCESSION LT708304-2393 PROTEIN_ID SIU00979.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mmpL9a" /locus_tag="BQ2027_MB2367" /note="Mb2367, mmpL9a, len: 826 aa. Equivalent to 5' end of Rv2339, len: 962 aa, from Mycobacterium tuberculosis strain H37Rv, (99.9% identity in 826 aa overlap). Probable mmpL9, conserved transmembrane transport protein (see citation below), with strong similarity to other Mycobacterial proteins e.g. P54881|YV34_MYCLE|MML4_MYCLE hypothetical 105.2 kd protein from Mycobacterium leprae (959 aa), FASTA scores: opt: 3799, E(): 0, (59.3% identity in 937 aa overlap); G699237|U1740AB from Mycobacterium leprae; and MTCY20G9.34; MTCY48.08c; MTCY19G5.06 from M. tuberculosis. BELONGS TO THE MMPL FAMILY. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, mmpL9 exists as a single gene. In Mycobacterium bovis, truncation due to a single base transition (g-a) splits mmpL9 into 2 parts, mmpL9a and mmpL9b, resulting in a shorter mmpL9a product. Mb2367 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3Y0X6" /db_xref="InterPro:IPR004869" /db_xref="UniProtKB/TrEMBL:A0A1R3Y0X6" BEGIN 1 MVPGEVHMSD TPSGPHPIIP RTIRLAAIPI LLCWLGFTVF VSVVVPPLEA IGETRAVAVA 61 PDDAQSMRAM RRAGKVFNEF DSNSIAMVVL ESDQPLGEKA HRYYDHLVDT LVLDQSHIQH 121 IQDFWRDPLT AAGAVSADGK AAYVQLYLAG NMGEALANES VEAVRKIVAN STPPEGIRTY 181 VTGPAALFAD QIAAGDRSMK LITGLTFAVI TVLLLLVYRS IATTLLILPM VFIGLGATRG 241 TIAFLGYHGM VGLSTFVVNI LTALAIAAGT DYAIFLVGRY QEARHIGQNR EASFYTMYRG 301 TANVILGSGL TIAGATYCLS FARLTLFHTM GPPLAIGMLV SVAAALTLAP AIIAIAGRFG 361 LLDPKRRLKT RGWRRVGTAV VRWPGPILAT SVALALVGLL ALPGYRPGYN DRYYLRAGTP 421 VNRGYAAADR HFGPARMNPE MLLVESDQDM RNPAGMLVID KIAKEVLHVS GVERVQAITR 481 PQGVPLEHAS IPFQISMMGA TQTMSLPYMR ERMADMLTMS DEMLVAINSM EQMLDLVQQL 541 NDVTHEMAAT TREIKATTSE LRDHLADIDD FVRPLRSYFY WEHHCFDIPL CSATRSLFDT 601 LDGVDTLTDQ LRALTDDMNK MEALTPQFLA LLPPMITTMK TMRTMMLTMR STISGVQDQM 661 ADMQDHATAM GQAFDTAKSG DSFYLPPEAF DNAEFQQGMK LFLSPNGKAV RFVISHESDP 721 ASTEGIDRIE AIRAATKDAI KATPLQGAKI YIGGTAATYQ DIRDGTKYDI LIVGIAAVCL 781 VFIVMLMITQ SLIASLVIVG TVLLSLGTAF GLSVLIWQHF VGLQVH //