LOCUS       SIU00921.1               542 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            conserved integral membrane transport protein YjcE protein.
ACCESSION   LT708304-2335
PROTEIN_ID  SIU00921.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="yjcE"
                     /locus_tag="BQ2027_MB2309"
                     /note="Mb2309, yjcE, len: 542 aa. Equivalent to Rv2287,
                     len: 542 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 542 aa overlap). Probable yjcE,
                     conserved integral membrane transport protein, similar to
                     eukaryote NA+/H+ exchangers e.g. YJCE_ECOLI|P32703|B4065
                     Putative Na(+)/H(+) exchanger from Escherichia coli (549
                     aa), FASTA scores: opt: 436, E(): 5.6e-21, (29.4% identity
                     in 555 aa overlap); etc. SEEMS TO BELONG TO CPA1 FAMILY
                     (NA(+)/H(+) EXCHANGER FAMILY)."
                     /db_xref="GOA:P65527"
                     /db_xref="InterPro:IPR004705"
                     /db_xref="InterPro:IPR006153"
                     /db_xref="InterPro:IPR018422"
                     /db_xref="UniProtKB/Swiss-Prot:P65527"
BEGIN
        1 MNGRRTIGED GLVFGLVVIV ALVAAVVVGT VLGHRYRVGP PVLLILSGSL LGLIPRFGDV
       61 QIDGEVVLLL FLPAILYWES MNTSFREIRW NLRVIVMFSI GLVIATAVAV SWTARALGME
      121 SHAAAVLGAV LSPTDAAAVA GLAKRLPRRA LTVLRGESLI NDGTALVLFA VTVAVAEGAA
      181 GIGPAALVGR FVVSYLGGIM AGLLVGGLVT LLRRRIDAPL EEGALSLLTP FAAFLLAQSL
      241 KCSGVVAVLV SALVLTYVGP TVIRARSRLQ AHAFWDIATF LINGSLWVFV GVQIPGAIDH
      301 IAGEDGGLPR ATVLALAVTG VVIATRIAWV QATTVLGHTV DRVLKKPTRH VGFRQRCVTS
      361 WAGFRGAVSL AAALAVPMTT NSGAPFPDRN LIIFVVSVVI LVTVLVQGTS LPTVVRWARM
      421 PEDVAHANEL QLARTRSAQA ALDALPTVAD ELGVAPDLVK HLEKEYEERA VLVMADGADS
      481 ATSDLAERND LVRRVRLGVL QHQRQAVTTL RNQNLIDDIV LRELQAAMDL EEVQLLDPAD
      541 AE
//