LOCUS SIU00912.1 299 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Possible glycerolphosphodiesterase protein. ACCESSION LT708304-2326 PROTEIN_ID SIU00912.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2300C" /note="Mb2300c, -, len: 299 aa. Equivalent to Rv2277c, len: 301 aa, from Mycobacterium tuberculosis strain H37Rv, (99.661% identity in 295 aa overlap). Possible glycerolphosphodiesterase, similar to e.g. UGPQ_ECOLI P10908 glycerophosphoryldiester phosphodiesterase (cytosolic) (247 aa), FASTA scores, opt: 149, E(): 0.0061, (27.2% identity in 195 aa overlap). Start of protein uncertain, encoded by neighbouring IS6110 as given, is intact in Mycobacterium tuberculosis CDC1551. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 1358 bp deletion containing an IS6110 sequence prior to the start of Mb2300c disrupts the 5' start of Rv2277c resulting in a slightly shorter product compared to the homolog in Mycobacterium tuberculosis strain H37Rv (299 aa versus 301 aa). Mb2300c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y0R7" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="UniProtKB/TrEMBL:A0A1R3Y0R7" BEGIN 1 MLGAVALVIA LGGTCGVADA LPLGQTDDPM IVAHRAGTRD FPENTVLAIT NAVAAGVDGM 61 WLTVQVSSDG VPVLYRPSDL ATLTDGAGPV NSKTVQQLQQ LNAGWNFTTP GVEGHPYRQR 121 ATPIPTLEQA IGATPPDMTL FLDPKQTPPQ PLVSAVAQVL TRTGAAGRSI VYSTNADITA 181 AASRQEGLQV AESRDVTRQR LFNMALNHHC DPQPDPGKWA GFELHRDVTV TEEFTLGSGI 241 SAVNAELWDE ASVDCFRSQS GMKVMGFAVK TVDDYRLAHK IGLDAVLVDS PLAAQQWRH //