LOCUS       SIU00897.1               317 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Possible
            oxidoreductase protein.
ACCESSION   LT708304-2311
PROTEIN_ID  SIU00897.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2286"
                     /note="Mb2286, -, len: 317 aa. Equivalent to Rv2263, len:
                     317 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 317 aa overlap). Possible
                     oxidoreductase (EC 1.-.-.-), similar to several
                     oxidoreductases. Similarity suggests alternative GTG start
                     at 10154 but then no rbs. FASTA scores: sptr|Q544
                     05|Q54405 PROBABLY AN NADP-DEPENDENT OXIDOREDUCTASE (297
                     aa) opt: 487, E(): 1.1e-23; (36.1% identity in 299 aa
                     overlap). Also similar to M. tuberculosis Rv0068, and
                     Rv0439c. Protein product from Mb2286 detected using SWATH
                     mass spectrometry. Mb2286 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y124"
BEGIN
        1 MAKDLVATVP DLSGKLAIIT GANSGLGFGL ARRLSAAGAD VIMAIRNRAK GEAAVEEIRT
       61 AVPDAKLTIK ALDLSSLASV AALGEQLMAD GRPIDLLINN AGVMTPPERV TTADGFELQF
      121 GSNHLGHFAL TAHLLPLLRA AQRARVVSLS SLAARRGRIH FDDLQFERSY APMTAYGQSK
      181 LAVLMFAREL DRRSRAAGWG IISNAAHPGL TKTNLQIAGP SHGRDKPALM ERLYKTSWRF
      241 APFLWQEIEE GILPALYAAA TPQADGGAFY GPRGRYEVAG GGVREAKVPA AARNDADSKR
      301 LWEVSEQLTG VSYPKSR
//