LOCUS SIU00897.1 317 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Possible oxidoreductase protein. ACCESSION LT708304-2311 PROTEIN_ID SIU00897.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2286" /note="Mb2286, -, len: 317 aa. Equivalent to Rv2263, len: 317 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 317 aa overlap). Possible oxidoreductase (EC 1.-.-.-), similar to several oxidoreductases. Similarity suggests alternative GTG start at 10154 but then no rbs. FASTA scores: sptr|Q544 05|Q54405 PROBABLY AN NADP-DEPENDENT OXIDOREDUCTASE (297 aa) opt: 487, E(): 1.1e-23; (36.1% identity in 299 aa overlap). Also similar to M. tuberculosis Rv0068, and Rv0439c. Protein product from Mb2286 detected using SWATH mass spectrometry. Mb2286 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="UniProtKB/TrEMBL:A0A1R3Y124" BEGIN 1 MAKDLVATVP DLSGKLAIIT GANSGLGFGL ARRLSAAGAD VIMAIRNRAK GEAAVEEIRT 61 AVPDAKLTIK ALDLSSLASV AALGEQLMAD GRPIDLLINN AGVMTPPERV TTADGFELQF 121 GSNHLGHFAL TAHLLPLLRA AQRARVVSLS SLAARRGRIH FDDLQFERSY APMTAYGQSK 181 LAVLMFAREL DRRSRAAGWG IISNAAHPGL TKTNLQIAGP SHGRDKPALM ERLYKTSWRF 241 APFLWQEIEE GILPALYAAA TPQADGGAFY GPRGRYEVAG GGVREAKVPA AARNDADSKR 301 LWEVSEQLTG VSYPKSR //