LOCUS       SIU00896.1               502 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Apolipoprotein
            N-acyltransferase protein.
ACCESSION   LT708304-2310
PROTEIN_ID  SIU00896.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2285C"
                     /note="Mb2285c, -, len: 502 aa. Equivalent to Rv2262c and
                     Rv2261c, len: 360 aa and 140 aa, from Mycobacterium
                     tuberculosis strain H37Rv, (94.7% identity in 357 aa
                     overlap and 100.0% identity in 140 aa overlap). Conserved
                     hypothetical protein, with function unknown but some
                     similarity to N-terminal 70% of
                     P23930|P77703|LNT_ECOLI|CUTE|B0657 APOLIPOPROTEIN
                     N-ACYLTRANSFERASE (EC 2.3.1.-) from Escherichia coli
                     strain K12 (512 aa), FASTA scores: opt: 239, E(): 1.6e-07,
                     (30.4% identity in 359 aa overlap). Note that neighboring
                     ORF shows similarity to N -terminal part of PCC6803
                     apolipoprotein N-acyltransferase from Synechocystis sp.,
                     suggesting possibility of frameshift. Sequence of clones
                     from two sources has been checked but no error found.
                     Appear to be two extra bases at position 1876970 compared
                     to CDC1551 strain. Conserved hypothetical protein, with
                     function unknown but some similarity to C-terminal end of
                     PCC6803 apolipoprotein N-acyltransferase from
                     Synechocystis sp. Note that next ORF shows similarity to
                     N-terminal part of P74055 APOLIPOPROTEIN N-ACYLTRANSFERASE
                     from Escherichia coli (519 aa), FASTA scores: opt: 142,
                     E(): 0.007, (29.9% identity in 117 aa overlap), suggesting
                     possible frameshift. Sequence of clones from two sources
                     has been checked but no error found.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv2262c and Rv2261c exist as 2
                     genes. In Mycobacterium bovis, a 2 bp deletion (ct-*)
                     results in a single product which is more similar to
                     Rv2262c."
                     /db_xref="GOA:A0A1R3Y0V4"
                     /db_xref="InterPro:IPR003010"
                     /db_xref="InterPro:IPR004563"
                     /db_xref="InterPro:IPR036526"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y0V4"
BEGIN
        1 MALRAGARRQ PVIGCAAALV FGGLPALAFP APSWWWLAWF GLVPLLLVVR AAPTSWEGAL
       61 RAWTGMGGFV LATQYWLVTS AGPMLVLLAA GLGVLWLPAG WLAHRLLSVP VTTCRVGAAL
      121 VVVPSAWVAA EAVRSWQSLG GPWALLGASQ WSQPVTLASA SLGGVWLTSF LLVATNTAIA
      181 SVLVCRATGG RLVALGCVIG CAGLGPASYL LGSVPVGGPT VRVALVQAGD IADAAARLAA
      241 GEEFTAAVAD QRPDLVVWGE SSVGQDLTRH PDVLARLAEL SQRVGADLLV NVDAPAPDGG
      301 IYKSAVLVGA HEAVGSYRKT RLVPFGEYVP LRPLFGWITR YSKAAAKDRQ RGAGPVVLAV
      361 NSLHIAPLIS YEMTFSDLTR HAARLGAALL VYQSSTSTFQ GSWAQPQLAA QPAVRAVEAG
      421 IPAVHASLSG DSSAFDTRGR RLAWCSAEFN GAIVVNVPLA SNVTLYLRLG DWVPVTAFVV
      481 MGAGFAVFLR RSLARVSDCA DK
//