LOCUS       SIU00894.1               361 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 s-nitrosomycothio
            l reductase mscr protein.
ACCESSION   LT708304-2308
PROTEIN_ID  SIU00894.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mscr"
                     /locus_tag="BQ2027_MB2283"
                     /note="Mb2283, adhE2, len: 361 aa. Equivalent to Rv2259,
                     len: 361 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 361 aa overlap). Probable adhE2,
                     zinc-containing alcohol dehydrogenase, similar to several,
                     especially mycothiol-dependent formaldehyde dehydrogenase
                     from Amycolatopsis methanolica P80094 (360 aa). Contains
                     PS00059 Zinc-containing alcohol dehydrogenases signature.
                     FASTA scores: >sp|P80094|FADH_AMYME
                     NAD/MYCOTHIOL-DEPENDENT FORMALDEHYDE DEHYDROGENASE
                     (MD-FALDH) Length = 360, Expect = e-156, Identities =
                     268/358 (74%). Also similar to Rv0162c, (MTCI28.02c, 35.0%
                     identity in 371 aa overlap). Protein product from Mb2283
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2283 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y2U2"
                     /db_xref="InterPro:IPR002328"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR017816"
                     /db_xref="InterPro:IPR020843"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y2U2"
BEGIN
        1 MSQTVRGVIA RQKGEPVELV NIVVPDPGPG EAVVDVTACG VCHTDLTYRE GGINDEYPFL
       61 LGHEAAGIIE AVGPGVTAVE PGDFVILNWR AVCGQCRACK RGRPRYCFDT FNAEQKMTLT
      121 DGTELTAALG IGAFADKTLV HSGQCTKVDP AADPAVAGLL GCGVMAGLGA AINTGGVTRD
      181 DTVAVIGCGG VGDAAIAGAA LVGAKRIIAV DTDDTKLDWA RTFGATHTVN AREVDVVQAI
      241 GGLTDGFGAD VVIDAVGRPE TYQQAFYARD LAGTVVLVGV PTPDMRLDMP LVDFFSHGGA
      301 LKSSWYGDCL PESDFPTLID LYLQGRLPLQ RFVSERIGLE DVEEAFHKMH GGKVLRSVVM
      361 L
//