LOCUS       SIU00861.1               364 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 multifunctional
            protein. has rnase h,alpha-ribazole phosphatase, and acid
            phosphatase activities. protein.
ACCESSION   LT708304-2275
PROTEIN_ID  SIU00861.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2253C"
                     /note="Mb2253c, -, len: 364 aa. Equivalent to Rv2228c,
                     len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 364 aa overlap). Conserved
                     hypothetical protein. Some similarity to phosphoglycerate
                     mutase and ribonuclease H. Similar to CAB88177.1|AL352972
                     putative bifunctional protein (ribonuclease
                     H/phosphoglycerate mutase) from Streptomyces coelicolor
                     A3(2) (497 aa); Smith-Waterman scores: 107 bits (424),
                     Expect = 4e-41 Identities = 160/485 (32%). Also similar in
                     C-terminal part to Rv2419c and Rv2135c. Protein product
                     from Mb2253c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb2253c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P64956"
                     /db_xref="InterPro:IPR002156"
                     /db_xref="InterPro:IPR012337"
                     /db_xref="InterPro:IPR013078"
                     /db_xref="InterPro:IPR014636"
                     /db_xref="InterPro:IPR029033"
                     /db_xref="InterPro:IPR036397"
                     /db_xref="UniProtKB/Swiss-Prot:P64956"
BEGIN
        1 MKVVIEADGG SRGNPGPAGY GAVVWTADHS TVLAESKQAI GRATNNVAEY RGLIAGLDDA
       61 VKLGATEAAV LMDSKLVVEQ MSGRWKVKHP DLLKLYVQAQ ALASQFRRIN YEWVPRARNT
      121 YADRLANDAM DAAAQSAAAD ADPAKIVATE SPTSPGWTGA RGTPTRLLLL RHGQTELSEQ
      181 RRYSGRGNPG LNEVGWRQVG AAAGYLARRG GIAAVVSSPL QRAYDTAVTA ARALALDVVV
      241 DDDLVETDFG AWEGLTFAEA AERDPELHRR WLQDTSITPP GGESFDDVLR RVRRGRDRII
      301 VGYEGATVLV VSHVTPIKML LRLALDAGSG VLYRLHLDLA SLSIAEFYAD GASSVRLVNQ
      361 TGYL
//