LOCUS       SIU00853.1               994 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 GLUTAMATE-
            AMMONIA-LIGASE ADENYLYLTRANSFERASE GLNE (Glutamine-synthetase
            adenylyltransferase) protein.
ACCESSION   LT708304-2267
PROTEIN_ID  SIU00853.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="glnE"
                     /locus_tag="BQ2027_MB2245C"
                     /note="Mb2245c, glnE, len: 994 aa. Equivalent to Rv2221c,
                     len: 994 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 994 aa overlap). glnE,
                     glutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42)
                     (see citations below), similar to others e.g.
                     GLNE_ECOLI|P30870 glutamate-ammonia-ligase
                     adenylyltransferase from Escherichia coli, FASTA score:
                     (24.4% identity in 721 aa overlap); GLNE_HAEIN|P44419
                     Glutamate-ammonia-ligase adenylyltransferase from
                     Haemophilus influenzae (981 aa), FASTA score: (28.1%
                     identity in 199 aa overlap); etc. Note that initiation
                     codon uncertain. Protein product from Mb2245c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2245c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P69941"
                     /db_xref="InterPro:IPR005190"
                     /db_xref="InterPro:IPR013546"
                     /db_xref="InterPro:IPR023057"
                     /db_xref="UniProtKB/Swiss-Prot:P69941"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MVVTKLATQR PKLPSVGRLG LVDPPAGERL AQLGWDRHED QAHVDLLWSL SRAPDADAAL
       61 RALIRLSENP DTGWDELNAA LLRERSLRGR LFSVLGSSLA LGDHLVAHPQ SWKLLRGKVT
      121 LPSHDQLQRS FVECVEESEG MPGSLVHRLR TQYRDYVLML AALDLAATVE DEPVLPFTVV
      181 AARLADAADA ALAAALRVAE ASVCGEHPPP RLAVIAMGKC GARELNYVSD VDVIFVAERS
      241 DPRNARVASE MMRVASAAFF EVDAALRPEG RNGELVRTLE SHIAYYQRWA KTWEFQALLK
      301 ARPVVGDAEL GERYLTALMP MVWRACERED FVVEVQAMRR RVEQLVPADV RGRELKLGSG
      361 GLRDVEFAVQ LLQLVHARSD ESLRVASTVD ALAALGEGGY IGREDAANMT ASYEFLRLLE
      421 HRLQLQRLKR THLLPDPEDE EAVRWLARAA HIRPDGRNDA AGVLREELKK QNVRVSKLHT
      481 KLFYQPLLES IGPTGLEIAH GMTLEAAGRR LAALGYEGPQ TALKHMSALV NQSGRRGRVQ
      541 SVLLPRLLDW MSYAPDPDGG LLAYRRLSEA LATESWYLAT LRDKPAVAKR LMHVLGTSAY
      601 VPDLLMRAPR VIQQYEDGPA GPKLLETEPA AVARALIASA SRYPDPERAI AGARTLRRRE
      661 LARIGSADLL GLLEVTEVCR ALTSVWVAVL QAALDVMIRA SLPDDDRAPA AIAVIGMGRL
      721 GGAELGYGSD ADVMFVCEPA TGVDDARAVK WSTSIAERVR ALLGTPSVDP PLELDANLRP
      781 EGRNGPLVRT LGSYAAYYEQ WAQPWEIQAL LRAHAVAGDA ELGQRFLRMV DKTRYPPDGV
      841 SADSVREIRR IKARIESERL PRGADPNTHT KLGRGGLADI EWTVQLLQLQ HAHQVPALHN
      901 TSTLQSLDVI AAADLVPAAD VELLRQAWLT ATRARNALVL VRGKPTDQLP GPGRQLNAVA
      961 VAAGWRNDDG GEFLDNYLRV TRRAKAVVRK VFGS
//