LOCUS       SIU00833.1               324 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 adenosine
            kinase protein.
ACCESSION   LT708304-2247
PROTEIN_ID  SIU00833.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="adok"
                     /locus_tag="BQ2027_MB2225C"
                     /note="Mb2225c, cbhK, len: 324 aa. Equivalent to Rv2202c,
                     len: 324 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 324 aa overlap). Probable cbhK,
                     carbohydrate kinase (but not ribose) (EC 2.7.-.-), similar
                     to several e.g. AE000915_1 Methanobacterium thermoautotrop
                     (309 aa) FASTA score: opt: 370, E(): 3.3e-18; 31.2%
                     identity in 276 aa overlap. Low similarity to carbohydrate
                     kinases, e.g. SW:RBSK_BACSU P36945 ribokinase (23.9%
                     identity in 272 aa overlap); contains PS00583 pfkB family
                     of carbohydrate kinases signature 1 Protein product from
                     Mb2225c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb2225c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P83736"
                     /db_xref="InterPro:IPR002173"
                     /db_xref="InterPro:IPR011611"
                     /db_xref="InterPro:IPR029056"
                     /db_xref="PDB:4UBE"
                     /db_xref="UniProtKB/Swiss-Prot:P83736"
BEGIN
        1 MTIAVTGSIA TDHLMRFPGR FSEQLLPEHL HKVSLSFLVD DLVMHRGGVA GNMAFAIGVL
       61 GGEVALVGAA GADFADYRDW LKARGVNCDH VLISETAHTA RFTCTTDVDM AQIASFYPGA
      121 MSEARNIKLA DVVSAIGKPE LVIIGANDPE AMFLHTEECR KLGLAFAADP SQQLARLSGE
      181 EIRRLVNGAA YLFTNDYEWD LLLSKTGWSE ADVMAQIDLR VTTLGPKGVD LVEPDGTTIH
      241 VGVVPETSQT DPTGVGDAFR AGFLTGRSAG LGLERSAQLG SLVAVLVLES TGTQEWQWDY
      301 EAAASRLAGA YGEHAAAEIV AVLA
//