LOCUS       SIU00829.1               299 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED MEMBRANE PROTEIN MMPS3 protein.
ACCESSION   LT708304-2243
PROTEIN_ID  SIU00829.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mmpS3"
                     /locus_tag="BQ2027_MB2221C"
                     /note="Mb2221c, mmpS3, len: 299 aa. Equivalent to Rv2198c,
                     len: 299 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 299 aa overlap). Probable mmpS3,
                     conserved membrane protein (see citation below),
                     equivalent to ML0877|mmpS3 putative membrane protein from
                     Mycobacterium leprae (293 aa), FASTA scores: opt: 1089,
                     E(): 1.2e-43, (69.80% identity in 308 aa overlap). Also
                     similar to other proteins e.g. Rv3209 from Mycobacterium
                     tuberculosis. Contains PS00499 C2 domain signature, a
                     hydrophobic region, and a repetitive proline and threonine
                     rich region. BELONGS TO THE MMPS FAMILY. Protein product
                     from Mb2221c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb2221c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P65379"
                     /db_xref="InterPro:IPR008693"
                     /db_xref="InterPro:IPR038468"
                     /db_xref="UniProtKB/Swiss-Prot:P65379"
BEGIN
        1 MSGPNPPGRE PDEPESEPVS DTGDERASGN HLPPVAGGGD KLPSDQTGET DAYSRAYSAP
       61 ESEHVTGGPY VPADLRLYDY DDYEESSDLD DELAAPRWPW VVGVAAIIAA VALVVSVSLL
      121 VTRPHTSKLA TGDTTSSAPP VQDEITTTKP APPPPPPAPP PTTEIPTATE TQTVTVTPPP
      181 PPPPATTTAP PPATTTTAAA PPPTTTTPTG PRQVTYSVTG TKAPGDIISV TYVDAAGRRR
      241 TQHNVYIPWS MTVTPISQSD VGSVEASSLF RVSKLNCSIT TSDGTVLSSN SNDGPQTSC
//