LOCUS SIU00829.1 299 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE CONSERVED MEMBRANE PROTEIN MMPS3 protein. ACCESSION LT708304-2243 PROTEIN_ID SIU00829.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mmpS3" /locus_tag="BQ2027_MB2221C" /note="Mb2221c, mmpS3, len: 299 aa. Equivalent to Rv2198c, len: 299 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 299 aa overlap). Probable mmpS3, conserved membrane protein (see citation below), equivalent to ML0877|mmpS3 putative membrane protein from Mycobacterium leprae (293 aa), FASTA scores: opt: 1089, E(): 1.2e-43, (69.80% identity in 308 aa overlap). Also similar to other proteins e.g. Rv3209 from Mycobacterium tuberculosis. Contains PS00499 C2 domain signature, a hydrophobic region, and a repetitive proline and threonine rich region. BELONGS TO THE MMPS FAMILY. Protein product from Mb2221c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2221c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P65379" /db_xref="InterPro:IPR008693" /db_xref="InterPro:IPR038468" /db_xref="UniProtKB/Swiss-Prot:P65379" BEGIN 1 MSGPNPPGRE PDEPESEPVS DTGDERASGN HLPPVAGGGD KLPSDQTGET DAYSRAYSAP 61 ESEHVTGGPY VPADLRLYDY DDYEESSDLD DELAAPRWPW VVGVAAIIAA VALVVSVSLL 121 VTRPHTSKLA TGDTTSSAPP VQDEITTTKP APPPPPPAPP PTTEIPTATE TQTVTVTPPP 181 PPPPATTTAP PPATTTTAAA PPPTTTTPTG PRQVTYSVTG TKAPGDIISV TYVDAAGRRR 241 TQHNVYIPWS MTVTPISQSD VGSVEASSLF RVSKLNCSIT TSDGTVLSSN SNDGPQTSC //