LOCUS       SIU00818.1               400 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            long-chain-fatty-acid-CoA ligase fadD15 (FATTY-ACID-CoA
            SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) protein.
ACCESSION   LT708304-2232
PROTEIN_ID  SIU00818.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadD15"
                     /locus_tag="BQ2027_MB2210"
                     /note="Mb2210, fadD15, len: 508 aa. Equivalent to 3' end
                     of Rv2187, len: 600 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (99.6% identity in 508 aa overlap). Probable
                     fadD15, long-chain-fatty-acid-CoA ligase (EC 6.2.1.3),
                     similar to several e.g. P44446|LCFH_HAEIN PUTATIVE
                     LONG-CHAIN-FATTY-ACID--CoA LIGASE from Haemophilus
                     influenzae (607 aa), FASTA scores: (607 aa) opt: 992, E():
                     0, (31.5% identity in 578 aa overlap); etc. Contains
                     PS00455 Putative AMP-binding domain signature. BELONGS TO
                     THE ATP-DEPENDENT AMP-BINDING ENZYME FAMILY. TBparse score
                     is 0.902. REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     bovis, a frameshift due to single base deletion (t-*)
                     leads to a shorter product with a different NH2 part
                     compared to its homolog in Mycobacterium tuberculosis
                     strain H37Rv. Protein product from Mb2210 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb2210 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:Q7TYX8"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="InterPro:IPR042099"
                     /db_xref="UniProtKB/Swiss-Prot:Q7TYX8"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTQSNLVHEI KGARAYHPTL LRKGERLLVF LPLAHVLARA ISMAAFHSKV TVGFTSDIKN
       61 LLPMLAVFKP TVVVSVPRVF EKVYNTAEQN AANAGKGRIF AIAAQTAVDW SEACDRGGPG
      121 LLLRAKHAVF DRLVYRKLRA ALGGNCRAAV SGGAPLGARL GHFYRGAGLT IYEGYGLSET
      181 SGGVAISQFN DLKIGTVGKP VPGNSLRIAD DGELLVRGGV VFSGYWRNEQ ATTEAFTDGW
      241 FKTGDLGAVD EDGFLTITGR KKEIIVTAGG KNVAPAVLED QLRAHPLISQ AVVVGDAKPF
      301 IGALITIDPE AFEGWKQRNS KTAGASVGDL ATDPDLIAEI DAAVKQANLA VSHAESIRKF
      361 RILPVDFTED TGELTPTMKV KRKVVAEKFA SDIEAIYNKE
//