LOCUS       SIU00792.1               206 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED
            HYPOTHETICAL PROTEIN protein.
ACCESSION   LT708304-2206
PROTEIN_ID  SIU00792.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2184C"
                     /note="Mb2184c, -, len: 206 aa. Similar to 5' end of
                     Rv2160A and 3' end of Rv2160c, len: 211 aa and 112 aa,
                     from Mycobacterium tuberculosis strain H37Rv, (96.3%
                     identity in 107 aa overlap and 92.0% identity in 112 aa
                     overlap). Conserved hypothetical protein, possibly a
                     tetR-family transcriptional regulator, similar to
                     N-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE
                     TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces
                     coelicolor (200 aa), FASTA scores: opt: 285, E(): 1.4e-08,
                     (51.042% identity in 96 aa overlap). Next gene, Rv2160c,
                     is similar to C-terminal half of 2SCK31.01c suggesting
                     possible frameshift near 2421978 but sequence of this
                     region has been checked and is also identical in strain
                     CDC1551. Conserved hypothetical protein, possibly a
                     tetR-family transcriptional regulator, similar to
                     C-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE
                     TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces
                     coelicolor (200 aa), while Rv2160A is similar to the
                     N-terminal half of 2SCK31.01c. This suggests possible
                     frameshift near 2421978 but sequence of this region has
                     been checked and is also identical in strain CDC1551.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2
                     genes with an overlap region between them. In
                     Mycobacterium bovis, a 4 bp insertion (*-ggaa) leads to a
                     single product."
                     /db_xref="GOA:A0A1R3Y0F7"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR036271"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y0F7"
BEGIN
        1 MPSADVGRQT RAQILRAAMD IASVKGLSGL SIGELAGRLG MSKSGLFRHF GAKEQLQLAT
       61 VEAAVSVFEA EVVAPAMAAP PGVDRVRALM HAWVGYLERD VFPGGCFFAA AAADVDSQPG
      121 PVRDRIAATG RAGIAAITAD VETAQRRGEI RADIEARQLA FELHAYAMEA NWALLLLDDD
      181 GAGERARTAI DAALARVGTT QEGVES
//