LOCUS SIU00792.1 206 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED HYPOTHETICAL PROTEIN protein. ACCESSION LT708304-2206 PROTEIN_ID SIU00792.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB2184C" /note="Mb2184c, -, len: 206 aa. Similar to 5' end of Rv2160A and 3' end of Rv2160c, len: 211 aa and 112 aa, from Mycobacterium tuberculosis strain H37Rv, (96.3% identity in 107 aa overlap and 92.0% identity in 112 aa overlap). Conserved hypothetical protein, possibly a tetR-family transcriptional regulator, similar to N-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 aa), FASTA scores: opt: 285, E(): 1.4e-08, (51.042% identity in 96 aa overlap). Next gene, Rv2160c, is similar to C-terminal half of 2SCK31.01c suggesting possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551. Conserved hypothetical protein, possibly a tetR-family transcriptional regulator, similar to C-terminal half of AL512667_12|Q9AD73|SCK31.01c PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (200 aa), while Rv2160A is similar to the N-terminal half of 2SCK31.01c. This suggests possible frameshift near 2421978 but sequence of this region has been checked and is also identical in strain CDC1551. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv2160A and Rv2160c exist as 2 genes with an overlap region between them. In Mycobacterium bovis, a 4 bp insertion (*-ggaa) leads to a single product." /db_xref="GOA:A0A1R3Y0F7" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="UniProtKB/TrEMBL:A0A1R3Y0F7" BEGIN 1 MPSADVGRQT RAQILRAAMD IASVKGLSGL SIGELAGRLG MSKSGLFRHF GAKEQLQLAT 61 VEAAVSVFEA EVVAPAMAAP PGVDRVRALM HAWVGYLERD VFPGGCFFAA AAADVDSQPG 121 PVRDRIAATG RAGIAAITAD VETAQRRGEI RADIEARQLA FELHAYAMEA NWALLLLDDD 181 GAGERARTAI DAALARVGTT QEGVES //