LOCUS       SIU00753.1                93 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 phosphoribosyl-
            amp pyrophosphatase hise protein.
ACCESSION   LT708304-2167
PROTEIN_ID  SIU00753.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hisE"
                     /locus_tag="BQ2027_MB2146C"
                     /standard_name="irg1"
                     /note="Mb2146c, hisE, len: 93 aa. Equivalent to Rv2122c,
                     len: 93 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 93 aa overlap). Probable hisE
                     (alternate gene name: irg1), phosphoribosyl-AMP
                     cyclohydrolase (EC 3.6.1.31) (see citation below), similar
                     to N-terminus of e.g. HIS2_SYNY3 P74755 phosphoribosyl-AMP
                     cyclohydrolase (230 aa), FASTA scores; opt: 150, E():
                     4e-08, (37.9% identity in 87 aa overlap); etc. Note that
                     previously misnamed hisI. Protein product from Mb2146c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry."
                     /db_xref="GOA:P0A5B2"
                     /db_xref="InterPro:IPR008179"
                     /db_xref="InterPro:IPR021130"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5B2"
BEGIN
        1 MQQSLAVKTF EDLFAELGDR ARTRPADSTT VAALDGGVHA LGKKLLEEAG EVWLAAEHES
       61 NDALAEEISQ LLYWTQVLMI SRGLSLDDVY RKL
//