LOCUS SIU00753.1 93 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 phosphoribosyl- amp pyrophosphatase hise protein. ACCESSION LT708304-2167 PROTEIN_ID SIU00753.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="hisE" /locus_tag="BQ2027_MB2146C" /standard_name="irg1" /note="Mb2146c, hisE, len: 93 aa. Equivalent to Rv2122c, len: 93 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 93 aa overlap). Probable hisE (alternate gene name: irg1), phosphoribosyl-AMP cyclohydrolase (EC 3.6.1.31) (see citation below), similar to N-terminus of e.g. HIS2_SYNY3 P74755 phosphoribosyl-AMP cyclohydrolase (230 aa), FASTA scores; opt: 150, E(): 4e-08, (37.9% identity in 87 aa overlap); etc. Note that previously misnamed hisI. Protein product from Mb2146c detected using shotgun mass spectrometry and SWATH mass spectrometry." /db_xref="GOA:P0A5B2" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="UniProtKB/Swiss-Prot:P0A5B2" BEGIN 1 MQQSLAVKTF EDLFAELGDR ARTRPADSTT VAALDGGVHA LGKKLLEEAG EVWLAAEHES 61 NDALAEEISQ LLYWTQVLMI SRGLSLDDVY RKL //