LOCUS       SIU00723.1               375 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 dipeptidase
            pepe protein.
ACCESSION   LT708304-2137
PROTEIN_ID  SIU00723.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pepE"
                     /locus_tag="BQ2027_MB2116C"
                     /note="Mb2116c, pepE, len: 375 aa. Equivalent to Rv2089c,
                     len: 375 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 375 aa overlap). Probable pepE,
                     dipeptidase, similar to e.g. PEPQ_LACDL P46545, xaa-pro
                     dipeptidase (368 aa), FASTA scores, opt: 617, E(): 5.1
                     e-32, (34.7% identity in 363 aa overlap); contains PS00491
                     Aminopeptidase P and proline dipeptidase signature. Also
                     similar to Mycobacterium tuberculosis peptidases Rv2861c,
                     Rv0734, Rv2535c. Protein product from Mb2116c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2116c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P65811"
                     /db_xref="InterPro:IPR000587"
                     /db_xref="InterPro:IPR000994"
                     /db_xref="InterPro:IPR001131"
                     /db_xref="InterPro:IPR029149"
                     /db_xref="InterPro:IPR036005"
                     /db_xref="UniProtKB/Swiss-Prot:P65811"
BEGIN
        1 MGSRRFDAEV YARRLALAAA ATADAGLAGL VITPGYDLCY LIGSRAETFE RLTALVLPAA
       61 GAPAVVLPRL ELAALKQSAA AELGLRVCDW VDGDDPYGLV SAVLGGAPVA TAVTDSMPAL
      121 HMLPLADALG VLPVLATDVL RRLRMVKEET EIDALRKAGA AIDRVHARVP EFLVPGRTEA
      181 DVAADIAEAI VAEGHSEVAF VIVGSGPHGA DPHHGYSDRE LREGDIVVVD IGGTYGPGYH
      241 SDSTRTYSIG EPDSDVAQSY SMLQRAQRAA FEAIRPGVTA EQVDAAARDV LAEAGLAEYF
      301 VHRTGHGIGL CVHEEPYIVA GNDLVLVPGM AFSIEPGIYF PGRWGARIED IVIVTEDGAV
      361 SVNNCPHELI VVPVS
//