LOCUS SIU00723.1 375 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 dipeptidase pepe protein. ACCESSION LT708304-2137 PROTEIN_ID SIU00723.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="pepE" /locus_tag="BQ2027_MB2116C" /note="Mb2116c, pepE, len: 375 aa. Equivalent to Rv2089c, len: 375 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 375 aa overlap). Probable pepE, dipeptidase, similar to e.g. PEPQ_LACDL P46545, xaa-pro dipeptidase (368 aa), FASTA scores, opt: 617, E(): 5.1 e-32, (34.7% identity in 363 aa overlap); contains PS00491 Aminopeptidase P and proline dipeptidase signature. Also similar to Mycobacterium tuberculosis peptidases Rv2861c, Rv0734, Rv2535c. Protein product from Mb2116c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb2116c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P65811" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="UniProtKB/Swiss-Prot:P65811" BEGIN 1 MGSRRFDAEV YARRLALAAA ATADAGLAGL VITPGYDLCY LIGSRAETFE RLTALVLPAA 61 GAPAVVLPRL ELAALKQSAA AELGLRVCDW VDGDDPYGLV SAVLGGAPVA TAVTDSMPAL 121 HMLPLADALG VLPVLATDVL RRLRMVKEET EIDALRKAGA AIDRVHARVP EFLVPGRTEA 181 DVAADIAEAI VAEGHSEVAF VIVGSGPHGA DPHHGYSDRE LREGDIVVVD IGGTYGPGYH 241 SDSTRTYSIG EPDSDVAQSY SMLQRAQRAA FEAIRPGVTA EQVDAAARDV LAEAGLAEYF 301 VHRTGHGIGL CVHEEPYIVA GNDLVLVPGM AFSIEPGIYF PGRWGARIED IVIVTEDGAV 361 SVNNCPHELI VVPVS //