LOCUS       SIU00706.1                62 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            precorrin-6y methyltransferase CobLa [FIRST PART] protein.
ACCESSION   LT708304-2120
PROTEIN_ID  SIU00706.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cobLa"
                     /locus_tag="BQ2027_MB2099C"
                     /note="Mb2099c, cobLa, len: 62 aa. Similar to 5' end of
                     Rv2072c, len: 390 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (97.727% identity in 44 aa overlap).
                     Probable cobL, methyl transferase (EC 2.1.1.132), similar
                     to L21196|g347169|RERCOBLMK1 from Rhodocococcus sp.
                     NI86/21 (447 aa), FASTA scores: opt: 892; E(): 0; (50.1%
                     identity in 369 aa overlap), and to COBL_PSEDE|P21921
                     precorrin-6y methylase (413 aa), FASTA scores: opt: 830,
                     E(): 0, (40.6% identity in 404 aa overlap).
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     large deletion of 2029 bp (H37Rv2.2330073-2332101-*) (RD9)
                     leads to the loss of the NH2 part of cobL, the entire
                     Rv2073 and Rv2074, and the COOH part of Mb2100c. In
                     addition, while cobL exists as a single gene in
                     Mycobacterium tuberculosis strain H37Rv, in Mycobacterium
                     bovis a frameshift due to a single base insertion (*-t)
                     splits cobL into 2 parts, cobLa and cobLb. Mb2099c found
                     to be expressed during exponential growth in Sauton's
                     minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y058"
                     /db_xref="InterPro:IPR035996"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y058"
BEGIN
        1 MLPAVQGLSP DGADLHVVAS GDPLLHGIGS TLIRLFGHDN VTVFAARVRG DVGVRPDGLE
       61 RV
//