LOCUS       SIU00701.1               307 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CLASS
            A BETA-LACTAMASE BLAC protein.
ACCESSION   LT708304-2115
PROTEIN_ID  SIU00701.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="blaC"
                     /locus_tag="BQ2027_MB2094C"
                     /note="Mb2094c, blaC, len: 307 aa. Equivalent to Rv2068c,
                     len: 307 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 307 aa overlap). blaC, class A
                     beta-lactamase (EC 3.5.2.6) (see citation below), similar
                     to e.g. BLAC_NOCLA Q06316 beta-lactamase precursor (302
                     aa), FASTA scores, opt: 860, E(): 0, (50.2% identity in
                     283 aa overlap); eyc. Contains PS00013 Prokaryotic lipid
                     attachment site near N-terminus, and PS00146
                     Beta-lactamase class-A active site. BELONGS TO THE CLASS-C
                     BETA-LACTAMASE FAMILY. Protein product from Mb2094c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb2094c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A5I7"
                     /db_xref="InterPro:IPR000871"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="InterPro:IPR023650"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5I7"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MRNRGFGRRE LLVAMAMLVS VTGCARHASG ARPASTTLPA GADLADRFAE LERRYDARLG
       61 VYVPATGTTA AIEYRADERF AFCSTFKAPL VAAVLHQNPL THLDKLITYT SDDIRSISPV
      121 AQQHVQTGMT IGQLCDAAIR YSDGTAANLL LADLGGPGGG TAAFTGYLRS LGDTVSRLDA
      181 EEPELNRDPP GDERDTTTPH AIALVLQQLV LGNALPPDKR ALLTDWMARN TTGAKRIRAG
      241 FPADWKVIDK TGTGDYGRAN DIAVVWSPTG VPYVVAVMSD RAGGGYDAEP REALLAEAAT
      301 CVAGVLA
//