LOCUS       SIU00678.1               511 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 carboxylesterase 
            lipt protein.
ACCESSION   LT708304-2091
PROTEIN_ID  SIU00678.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="lipT"
                     /locus_tag="BQ2027_MB2071C"
                     /note="Mb2071c, lipT, len: 511 aa. Equivalent to Rv2045c,
                     len: 511 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 511 aa overlap). Probable lipT,
                     carboxylesterase similar to many e.g. O08472 (489 aa) and
                     P37967|PNBA_ BACSU (489 aa). PARA-NITROBENZYL ESTERASE (EC
                     3.1.1.-). Contains PS00941 Carboxylesterases type-B
                     signature 2. Contains PS00122 Carboxylesterases type-B
                     serine active site. FASTA scores: sptr|O08472|O08472
                     INTRACELLULAR ESTERASE B (489 aa) opt: 849, E(): 0, (36.2%
                     identity in 489 aa overlap) and sp|P37967|PNBA_BACSU
                     PARA-NITROBENZYL ESTERASE (489 aa) opt: 838, E(): 0,
                     (36.0% identity in 489 aa overlap). TBparse score is 0
                     .918 Protein product from Mb2071c detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb2071c
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3Y007"
                     /db_xref="InterPro:IPR002018"
                     /db_xref="InterPro:IPR002168"
                     /db_xref="InterPro:IPR019819"
                     /db_xref="InterPro:IPR019826"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y007"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MALESATVGS MHERTVRART ATGIVEGFTR DGVHRWRSIP YARAPVGSLR FRAPQPAQPW
       61 PGVRHCHTFA NCAPQQRRYT VMGIGRYQTR SEDCLTLNVV TPEEPATQPL PVMVFIHGGG
      121 YILGSSATPI YDGAALARRG CVYVSVNYRL GALGCLDLSS LSTPQITLDS NVYLRDLVLA
      181 LRWVHDNIAE FGGDPGNVTI FGESAGAHIT ATLLAVPAAK GLFARAISES PAAGMVRSRE
      241 VAAEFAARFA NLIGARTQDA ANALMQASPA QLVEAQHHLI RQGMRKRLGA FPIGPVFGDD
      301 YLPMDPVEAM RSGRVHAVPL IVGTNAEEGR LFTRFLGMLP TNEPMVEELL SGMKPADRER
      361 ITAAYPNYPA PSACIQLGGD FAFSSAAWQI AEAHGANAPT YLYRYDYAPR TLRWSGFGAT
      421 HATELFAVFD IYRTRFGALL TAAADRRAAL RVSNEVQRRW RCFSQIGVPG DDWPAYTQDD
      481 RAVLVFDRRC RIEFDPHQHR RIAWDGFSLA N
//