LOCUS       SIU00665.1               331 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Dinucleotide-
            utilizing enzymes involved in molybdopterin and thiamine
            biosynthesis family 2 protein.
ACCESSION   LT708304-2078
PROTEIN_ID  SIU00665.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="acg"
                     /locus_tag="BQ2027_MB2058"
                     /note="Mb2058, -, len: 331 aa. Equivalent to Rv2032, len:
                     331 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 331 aa overlap). acg (for
                     acr-coregulated gene), conserved hypothetical protein
                     possibly member of a superfamily of classical
                     nitroreductases (see first citation below), similar to
                     hypothetical mycobacterial proteins Rv3127|MTCY164.37 (344
                     aa) and Rv3131|MTCY03A2.27c (332 aa). FASTA scores:
                     Z95150|MTCY164_38 Mycobacterium tuberculosis cosmid (344
                     aa) opt: 1208, E(): 0, (56.4% identity in 321 aa overlap);
                     Z83867| MTCY3A2_27 Mycobacterium tuberculosis cosmid (332
                     aa) opt: 568, E(): 8.6e-30, (36.8% identity in 321 aa
                     overlap). Similar to proteins SCJ1.11 (330 aa; AL109962)
                     and SCJ12.27c (335 aa; AL109989) in Streptomyces
                     coelicolor. Protein product from Mb2058 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb2058 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y0T1"
                     /db_xref="InterPro:IPR000415"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y0T1"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MPDTMVTTDV IKSAVQLACR APSLHNSQPW RWIAEDHTVA LFLDKDRVLY ATDHSGREAL
       61 LGCGAVLDHF RVAMAAAGTT ANVERFPNPN DPLHLASIDF SPADFVTEGH RLRADAILLR
      121 RTDRLPFAEP PDWDLVESQL RTTVTADTVR IDVIADDMRP ELAAASKLTE SLRLYDSSYH
      181 AELFWWTGAF ETSEGIPHSS LVSAAESDRV TFGRDFPVVA NTDRRPEFGH DRSKVLVLST
      241 YDNERASLLR CGEMLSAVLL DATMAGLATC TLTHITELHA SRDLVAALIG QPATPQALVR
      301 VGLAPEMEEP PPATPRRLID EVFHVRAKDH R
//