LOCUS       SIU00662.1                79 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED
            HYPOTHETICAL PROTEIN [SECOND PART] protein.
ACCESSION   LT708304-2075
PROTEIN_ID  SIU00662.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB2055C"
                     /note="Mb2055c, -, len: 79 aa. Equivalent to 3' end of
                     Rv2030c, len: 681 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100.000% identity in 79 aa overlap).
                     Conserved hypothetical protein that corresponds to
                     products of two adjacent ORF's described previously
                     MSGTUBDWN_4 (390 aa) and MSGTUBDWN_1 (385 aa). Also
                     similar to C-terminal two-thirds of Mycobacterium
                     tuberculosis protein Rv2143 (MTCY270.25c; 352 aa) and to
                     Rv0571c (443 aa) and Mycobacterium leprae protein U650s
                     MLU15184_16 (258 aa). FASTA scores: M93129|MSGTUBDWN_4
                     (390 aa) opt: 2530 E(): 0; 97.7% identity in 385 aa
                     overlap and M93129|MSGTUBDWN_1 (385 aa) opt: 1983 E(): 0;
                     99.0% identity in 309 aa overlap. Z95388| MTCY270_25 (352
                     aa) opt: 882 E(): 0; 61.1 % identity in 226 aa overlap.
                     U15184|MLU15184_16 (258 aa) opt: 549 E(): 9.8e-29; 43.8%
                     identity in 219 aa overlap. REMARK-M.bovis-M.tuberculosis:
                     In Mycobacterium tuberculosis strain H37Rv, Rv2030c exists
                     as a single gene. In Mycobacterium bovis, a frameshift due
                     to a single base deletion (c-*) splits Rv2030c into 2
                     parts, Mb2055c and Mb2056c. Protein product from Mb2055c
                     detected using SWATH mass spectrometry. Mb2055c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y033"
                     /db_xref="InterPro:IPR007815"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y033"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSARLSRDAE APLDVVRLGR AIGVVYLPAT ERQSHYLHVR PADQFDAMIH IDQTRALEPL
       61 EVTSRWIAGE NPETYPTGL
//