LOCUS SIU00604.1 134 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE3A protein. ACCESSION LT708304-2017 PROTEIN_ID SIU00604.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="yrbE3A" /locus_tag="BQ2027_MB1999" /note="Mb1999, yrbE3A, len: 134 aa. Similar to 5' end of Rv1964, len: 265 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 102 aa overlap). yrbE3A, hypothetical unknown integral membrane protein, part of mce3 operon and member of YrbE family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265 aa), O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa), Rv3501c|MTV023.08c|yrbE4A (254 aa), etc. Also highly similar to conserved hypothetical integral membrane proteins of yrbEA type, e.g. AAD24544.1|AF116213|YrbE1A from Mycobacterium leprae (112 aa); P45392|YRBE_ECOLI from Escherichia coli (260 aa), FASTA scores: opt: 893, E(): 0, (51.4% identity in 253 aa overlap); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large deletion of 12719 bp (RD7) leads to the loss of the COOH part of yrbE3A, the entire mce3 operon and the following genes up to Mb2000 compared to Mycobacterium tuberculosis strain H37Rv. Mb1999 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y1Y6" /db_xref="InterPro:IPR030802" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1Y6" BEGIN 1 MVIVADKAAG RVADPVLRPV GALGDFFAMT LDTSVCMFKP PFAWREYLLQ CWFVARVSTL 61 PGVLMTIPWA VISGFLFNVL LTDIGAADFS GTGCAIFTVN QSRGTGSLER GRFIGPQDHR 121 VAAALEVTAP LLRS //