LOCUS       SIU00604.1               134 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED
            HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE3A protein.
ACCESSION   LT708304-2017
PROTEIN_ID  SIU00604.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="yrbE3A"
                     /locus_tag="BQ2027_MB1999"
                     /note="Mb1999, yrbE3A, len: 134 aa. Similar to 5' end of
                     Rv1964, len: 265 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100.0% identity in 102 aa overlap). yrbE3A,
                     hypothetical unknown integral membrane protein, part of
                     mce3 operon and member of YrbE family (see citations below
                     for more information), highly similar to Mycobacterium
                     tuberculosis proteins O07412|Rv0167|MTCI28.07|yrbE1A (265
                     aa), O07791|Rv0587|MTCY19H5.35|yrbE2A (265 aa),
                     Rv3501c|MTV023.08c|yrbE4A (254 aa), etc. Also highly
                     similar to conserved hypothetical integral membrane
                     proteins of yrbEA type, e.g. AAD24544.1|AF116213|YrbE1A
                     from Mycobacterium leprae (112 aa); P45392|YRBE_ECOLI from
                     Escherichia coli (260 aa), FASTA scores: opt: 893, E(): 0,
                     (51.4% identity in 253 aa overlap); etc.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     large deletion of 12719 bp (RD7) leads to the loss of the
                     COOH part of yrbE3A, the entire mce3 operon and the
                     following genes up to Mb2000 compared to Mycobacterium
                     tuberculosis strain H37Rv. Mb1999 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1Y6"
                     /db_xref="InterPro:IPR030802"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1Y6"
BEGIN
        1 MVIVADKAAG RVADPVLRPV GALGDFFAMT LDTSVCMFKP PFAWREYLLQ CWFVARVSTL
       61 PGVLMTIPWA VISGFLFNVL LTDIGAADFS GTGCAIFTVN QSRGTGSLER GRFIGPQDHR
      121 VAAALEVTAP LLRS
//