LOCUS SIU00603.1 406 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable transcriptional repressor (probably tetr-family) mce3r protein. ACCESSION LT708304-2016 PROTEIN_ID SIU00603.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mce3r" /locus_tag="BQ2027_MB1998C" /note="Mb1998c, -, len: 406 aa. Equivalent to Rv1963c, len: 406 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 406 aa overlap). Probable transcriptional regulatory protein, similar to several e.g. AL049485|SC6A5.30 Streptomyces coelicolor cosmid 6 A (404 aa), FASTA scores: opt: 319, E(): 6.4e-13, (29.5% identity in 373 aa overlap); and Z84498|MTCY9F9_1 (259 aa), FASTA scores: opt: 208, E(): 1.6e-07, (100.0% identity in 32 aa overlap). Contains probable helix-turn-helix at aa 36-57 (+4.23 SD). Protein product from Mb1998c detected using SWATH mass spectrometry. Mb1998c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XZU1" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="UniProtKB/TrEMBL:A0A1R3XZU1" BEGIN 1 MASVAQPVRR RPKDRKKQIL DQAVGLFIER GFHSVKLEDI AEAAGVTARA LYRHYDNKQA 61 LLAEAIRTGQ DQYQSARRLT EGETEPTPRP LNADLEDLIA AAVASRALTV LWQREARYLN 121 EDDRTAVRRR INAIVAGMRD SVLLEVPDLS PQHSELRAWA VSSTLTSLGR HSLSLPGEEL 181 KKLLYQACMA AARTPPVCEL PPLPAGDAAR DEADVLFSRY ETLLAAGARL FRAQGYPAVN 241 TSEIGKGAGI AGPGLYRSFS SKQAILDALI RRLDEWRCLE CIRALRANQQ AAQRLRGLVQ 301 GHVRISLDAP DLVAVSVTEL SHASVEVRDG YLRNQGDREA VWIDLIGKLV PATSVAQGRL 361 LVAAAISFIE DVARTWHLTR YAGVADEISG LALAILTSGA GNLLRA //