LOCUS       SIU00603.1               406 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            transcriptional repressor (probably tetr-family) mce3r
            protein.
ACCESSION   LT708304-2016
PROTEIN_ID  SIU00603.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mce3r"
                     /locus_tag="BQ2027_MB1998C"
                     /note="Mb1998c, -, len: 406 aa. Equivalent to Rv1963c,
                     len: 406 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 406 aa overlap). Probable
                     transcriptional regulatory protein, similar to several
                     e.g. AL049485|SC6A5.30 Streptomyces coelicolor cosmid 6 A
                     (404 aa), FASTA scores: opt: 319, E(): 6.4e-13, (29.5%
                     identity in 373 aa overlap); and Z84498|MTCY9F9_1 (259
                     aa), FASTA scores: opt: 208, E(): 1.6e-07, (100.0%
                     identity in 32 aa overlap). Contains probable
                     helix-turn-helix at aa 36-57 (+4.23 SD). Protein product
                     from Mb1998c detected using SWATH mass spectrometry.
                     Mb1998c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZU1"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZU1"
BEGIN
        1 MASVAQPVRR RPKDRKKQIL DQAVGLFIER GFHSVKLEDI AEAAGVTARA LYRHYDNKQA
       61 LLAEAIRTGQ DQYQSARRLT EGETEPTPRP LNADLEDLIA AAVASRALTV LWQREARYLN
      121 EDDRTAVRRR INAIVAGMRD SVLLEVPDLS PQHSELRAWA VSSTLTSLGR HSLSLPGEEL
      181 KKLLYQACMA AARTPPVCEL PPLPAGDAAR DEADVLFSRY ETLLAAGARL FRAQGYPAVN
      241 TSEIGKGAGI AGPGLYRSFS SKQAILDALI RRLDEWRCLE CIRALRANQQ AAQRLRGLVQ
      301 GHVRISLDAP DLVAVSVTEL SHASVEVRDG YLRNQGDREA VWIDLIGKLV PATSVAQGRL
      361 LVAAAISFIE DVARTWHLTR YAGVADEISG LALAILTSGA GNLLRA
//