LOCUS SIU00580.1 109 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 possible toxin mazf5 protein. ACCESSION LT708304-1993 PROTEIN_ID SIU00580.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mazf5" /locus_tag="BQ2027_MB1977C" /note="Mb1977c, -, len: 109 aa. Equivalent to Rv1942c, len: 109 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 109 aa overlap). Conserved hypothetical protein, shows some similarity to Q10867|MTCY39.28|Rv1991 hypothetical 12.3 kd protein (114 aa), FASTA scores: opt: 117, E(): 0.021, (24. 5% identity in 110 aa overlap) also P33645|CHPA_ECOLI pemk-like protein 1 (mazf protein) from Escherichia coli (111 aa), FASTA scores: opt: 104, E(): 0.18, (29.1% identity in 110 aa overlap). Also similar to Mycobacterium tuberculosis Rv0659c (102 aa) (32.7% identity in 101 aa overlap); Rv1102c (33.3% identity in 93 aa overlap) and Rv1495. Protein product from Mb1977c detected using SWATH mass spectrometry. Mb1977c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XZS9" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="UniProtKB/TrEMBL:A0A1R3XZS9" BEGIN 1 MTALPARGEV WWCEMAEIGR RPVVVLSRDA AIPRLRRALV APCTTTIRGL ASEVVLEPGS 61 DPIPRRSAVN LDSVESVSVA VLVNRLGRLA DIRMRAICTA LEVAVDCSR //