LOCUS       SIU00566.1               255 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE protein.
ACCESSION   LT708304-1979
PROTEIN_ID  SIU00566.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1963C"
                     /note="Mb1963c, -, len: 255 aa. Equivalent to Rv1928c,
                     len: 255 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 255 aa overlap). Probable short-chain
                     dehydrogenase/reductase (EC 1.-.-.-), highly similar to
                     others e.g. NP_228109.1|NC_000853 oxidoreductase (short
                     chain dehydrogenase/reductase family) from Thermotoga
                     maritima (257 aa); T41116 short chain dehydrogenase from
                     Schizosaccharomyces pombe (261 aa); P87219|SOU1_CANAL
                     SORBITOL UTILIZATION PROTEIN (SDR FAMILY) from Candida
                     albicans (281 aa); P25529|HDHA_ECOLI
                     7-alpha-hydroxysteroid dehydrogenase from Escherichia coli
                     (255 aa), FASTA scores: opt: 541, E(): 1.2e-27, (37.5%
                     identity in 251 aa overlap); etc. Also similar to many
                     mycobacterial tuberculosis proteins e.g. Rv1350, Rv0927c,
                     Rv2002, Rv0769, Rv2766c, etc. Contains PS00061 Short-chain
                     alcohol dehydrogenase family signature. BELONGS TO THE
                     SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.
                     Protein product from Mb1963c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1963c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZS7"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZS7"
BEGIN
        1 MSVLDLFDLH GKRALITGAS TGIGKRVALA YVEAGAQVAI AARHLDALEK LADEIGTSGG
       61 KVVPVCCDVS QHQQVTSMLD QVTAELGGID IAVCNAGIIT VTPMLDMPLE EFQRLQNTNV
      121 TGVFLTAQAA AKAMVKQGQG GVIINTASMS GHIINVPQQV SHYCASKAAV IHLTKAMAVE
      181 LAPHKIRVNS VSPGYILTEL VEPYTEYQPL WEPKIPLGRL GRPEELAGLY LYLASEASSY
      241 MTGSDIVIDG GYTCP
//