LOCUS       SIU00563.1               620 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            ACYL-COA LIGASE FADD31 (ACYL-COA SYNTHETASE) (ACYL-COA
            SYNTHASE) protein.
ACCESSION   LT708304-1976
PROTEIN_ID  SIU00563.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadD31"
                     /locus_tag="BQ2027_MB1960"
                     /note="Mb1960, fadD31, len: 620 aa. Equivalent to Rv1925,
                     len: 620 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 620 aa overlap). Probable fadD31,
                     acyl-CoA synthetase (EC 6.2.1.-), highly similar to others
                     from Mycobacterium leprae e.g. NP_301198.1|NC_002677
                     putative acyl-CoA synthetase (635 aa);
                     NP_302537.1|NC_002677 probable acyl-CoA synthase (583 aa);
                     etc. Also highly similar to others from Mycobacterium
                     tuberculosis e.g. fadD32 (637 aa); fadD21 (578 aa); fadD29
                     (619 aa); fadD26|FD26_MYCTU|Q10976 (626 aa), FASTA scores:
                     opt: 945, E(): 0, (39.8% identity in 598 aa overlap); etc.
                     Also similar to N-terminus of G1171128 SAFRAMYCIN MX1
                     SYNTHETASE B from Myxococcus xanthus (1770 aa), FASTA
                     scores: opt: 845, E(): 0, (37.4% identity in 593 aa
                     overlap); N-terminus of T34918 polyketide synthase from
                     Streptomyces coelicolor (2297 aa); etc. Protein product
                     from Mb1960 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb1960 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZQ8"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR040097"
                     /db_xref="InterPro:IPR042099"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZQ8"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MNDGSRQELR VRSGLLQIED CLDADGGIAL PAGTTLISLI ERNIKYVGDL VAYRYLDHAR
       61 SAAGCALEVT WTQFGMRLAA IGAHVQRFAG PGDRVAILAP QGIDYVCGFY AAIKAGTVAV
      121 PLFAPELPGH AERLDTALRD SEPAVILTTA AAKNAVEGFL NNVPRLRKPT VLVIDQIPDR
      181 EGELFVPVEL DIDAVSHLQY TSGSTRPPVG VEITHRAVGT NLVQMILSID LLNRNTHGVS
      241 WLPLYHDMGL SMIGFPAVYG GHSTLMSPTA FVRRPLRWIQ ALSEGSRTGR VVTAAPNFAY
      301 EWAAQRGLPA QGDDVDLSNV VLIIGSEPVS IDAVTTFNKA FAPYGLPRTA FKPSYGIAEA
      361 TLLVATIDHA AEPTVVYLDP EQLGAGHATR VAPDAPNAVV HVSCGHVARS LWAVIVDPDT
      421 GPEAGAELPD GEIGEVWLQG DNVARGYWGR PEETRMTFGA RLQSPLAEGS HADGSAIDDT
      481 WLRTGDLGVY LDGELYITGR IADLLTIDGR NHYPQDIEAT AAEASPMVRR GYITAFTVPA
      541 SDGDDRNQRL VIIAERAAGT SRSDPRPALD AIRAAVCNRH GLSVADLSFL PAGAIPRTTS
      601 GKLARQACRA QYLSGRLGVH
//