LOCUS       SIU00550.1               334 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            OXIDOREDUCTASE FADB5 protein.
ACCESSION   LT708304-1963
PROTEIN_ID  SIU00550.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadB5"
                     /locus_tag="BQ2027_MB1947C"
                     /note="Mb1947c, fadB5, len: 334 aa. Equivalent to Rv1912c,
                     len: 334 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 334 aa overlap). Possible fadB5,
                     oxidoreductase (EC 1.-.-.-), similar to various
                     oxidoreductases: 3-hydroxyacyl-CoA dehydrogenase (EC
                     1.1.1.35), quinone oxidoreductases (EC 1.6.5.5), and
                     polyketide synthases, e.g. NP_104067.1|NC_002678 probable
                     oxidoreductase from Mesorhizobium loti (308 aa);
                     NP_464140.1|NC_003210 protein similar to oxidoreductase
                     from Listeria monocytogenes (313 aa);
                     NP_193889.1|NC_003075 putative NADPH quinone
                     oxidoreductase from Arabidopsis thaliana (325 aa);
                     NP_001880.2|NM_001889 crystallin, zeta; quinone
                     oxidoreductase; NADPH:quinone reductase from Homo sapiens
                     (329 aa); part 2983 to 3197 of T17410 polyketide synthase
                     type I from Streptomyces venezuelae (3739 aa);
                     Q53927|SCBAC20F6.16 HYDROXYACYL-COA DEHYDROGENASE from
                     Streptomyces coelicolor (329 aa), FASTA scores: opt: 621,
                     E(): 2e-30, (39.5% identity in 349 aa overlap); etc. Also
                     similar to many hypothetical Mycobacterium tuberculosis
                     proteins including: MTCY24G1.09, MTCY13D12.11,
                     MTCY19H9.01, MTCY24G1.03, MTCY03A2.17c, etc. Contains
                     quinone oxidoreductase/zeta-crystallin signature
                     (PS01162). Protein product from Mb1947c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb1947c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZP6"
                     /db_xref="InterPro:IPR002364"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR020843"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZP6"
BEGIN
        1 MRAVVITKHG DPSVLQVRQR PDPPPPGPGQ LRVAVRAAGV NFADHLARVG LYPDAPKLPA
       61 VVGYEVAGTV EAVGDGVDPN RVGERVLAGT RFGGYCEIVN VAATDSVVLP DALSFEQGAA
      121 VPVNYATAWA ALHGYGSLRA GERVLIHAAA GGVGIAAVQF AKAAKAEVHG TASPQKHQKL
      181 AEFGVDRAID YRRDGWWQGL GPYDVVLDAL GGTSLRRSYT LLRPGGRLVG YGISNMQHGE
      241 KRSMRRVAPH ALSMLRGFNL MKQLEESKTV IGLNMLRLWD DRRTLEPWIA PLTKALNDGT
      301 ILPIVHAIVP FAEAPEAHRI LAARENVGKV VLVP
//