LOCUS       SIU00533.1               234 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            DEHYDROGENASE [SECOND PART] protein.
ACCESSION   LT708304-1946
PROTEIN_ID  SIU00533.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1929"
                     /note="Mb1929, -, len: 234 aa. Equivalent to middle part
                     of Rv1895, len: 384 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (97.9% identity in 234 aa overlap). Possible
                     dehydrogenase (EC 1.1.-.-), similar to various sorbitol
                     and alcohol dehydrogenases, and to putative
                     glutathione-dependent aldehyde dehydrogenase e.g
                     DHSO_BACSU|Q06004 Sorbitol dehydrogenase (EC 1.1.1.14)
                     from Streptomyces coelicolor (352 aa), FASTA results: opt:
                     506, E(): 7.2e-24, (30.6% identity in 350 aa overlap); and
                     AL109962|SCJ1.28 PUTATIVE ZINC-CONTAINING DEHYDROGENASE
                     from Streptomyces coelicolor (356 aa), FASTA results: opt:
                     634, E(): 2.9e-30, (34.7% identity in 357 aa overlap).
                     Also similar to other Mycobacterium tuberculosis
                     dehydrogenases. ****Note that there is a substantial (134
                     bp) overlap at the C-terminus with the C-terminus of the
                     downstream ORF, although both appear to be true coding
                     regions. REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv1895 exists as a single gene.
                     In Mycobacterium bovis, two frameshifts due to a single
                     base deletion (a-*) and a single base insertion (*-t),
                     consecutively, splits Rv1895 into 2 main parts, Mb1928 and
                     Mb1929."
                     /db_xref="GOA:A0A1R3XZM8"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZM8"
BEGIN
        1 MIFGAGVLGG AQADLLAVPA ADFQVLKIPE GITTEQALLL TDNLATGWAA AQRADISFGS
       61 AVAVIGLGAV GLCALRSAFI HGAATVFAVD RVKGRLQRAA TWGATPIPSP AAETILAATR
      121 GRGADSVIDA VGTDASMSDA LNAVRPGGTV SVVGVHDLQP FPLPALTCLL RSITLRMTMA
      181 PVQRTWPELI PLLQSGRLDV DGIFTTTLPL DEAAKGYATA RARSGEELKV LLTP
//