LOCUS       SIU00516.1               438 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            cytochrome p450 140 CYP140 protein.
ACCESSION   LT708304-1929
PROTEIN_ID  SIU00516.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cyp140"
                     /locus_tag="BQ2027_MB1912C"
                     /note="Mb1912c, cyp140, len: 438 aa. Equivalent to
                     Rv1880c, len: 438 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100.0% identity in 438 aa overlap).
                     Probable cyp140, cytochrome p450 (EC 1.14.-.-). Similar to
                     Q00441|CPXJ_SACER 6-deoxyerythronolide beta hydroxylase
                     (404 aa), FASTA scores: opt: 775, E(): 0, (44.2% identity
                     in 319 aa overlap); and other members of the cytochrome
                     P450 family. Related to Mycobacterium tuberculosis
                     proteins include: Rv0766c, Rv2266, Rv0778, etc. Contains
                     cytochrome P450 cysteine heme-iron ligand signature
                     (PS00086). BELONGS TO THE CYTOCHROME P450 FAMILY. Protein
                     product from Mb1912c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb1912c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P63722"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="InterPro:IPR036396"
                     /db_xref="UniProtKB/Swiss-Prot:P63722"
BEGIN
        1 MKDKLHWLAM HGVIRGIAAI GIRRGDLQAR LIADPAVATD PVPFYDEVRS HGALVRNRAN
       61 YLTVDHRLAH DLLRSDDFRV VSFGENLPPP LRWLERRTRG DQLHPLREPS LLAVEPPDHT
      121 RYRKTVSAVF TSRAVSALRD LVEQTAINLL DRFAEQPGIV DVVGRYCSQL PIVVISEILG
      181 VPEHDRPRVL EFGELAAPSL DIGIPWRQYL RVQQGIRGFD CWLEGHLQQL RHAPGDDLMS
      241 QLIQIAESGD NETQLDETEL RAIAGLVLVA GFETTVNLLG NGIRMLLDTP EHLATLRQHP
      301 ELWPNTVEEI LRLDSPVQLT ARVACRDVEV AGVRIKRGEV VVIYLAAANR DPAVFPDPHR
      361 FDIERPNAGR HLAFSTGRHF CLGAALARAE GEVGLRTFFD RFPDVRAAGA GSRRDTRVLR
      421 GWSTLPVTLG PARSMVSP
//