LOCUS SIU00504.1 411 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Probable reductase protein. ACCESSION LT708304-1917 PROTEIN_ID SIU00504.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB1900C" /note="Mb1900c, -, len: 411 aa. Equivalent to Rv1869c, len: 411 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 411 aa overlap). Probable reductase (1.-.-.-). Similar to several reductases e.g. CAC04223.1|AL391515 putative ferredoxin reductase from Streptomyces coelicolor (420 aa); THCD_RHOSO|P43494 rhodocoxin reductase (426 aa), FASTA scores: opt: 904, E(): 0, (40.8% identity in 370 aa overlap). Also similar to Mycobacterium tuberculosis proteins Rv0688 (406 aa) (39.9% identity in 391 aa overlap); and Rv0253 (nitrite reductase subunit). Protein product from Mb1900c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb1900c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3Y1Q6" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028202" /db_xref="InterPro:IPR036188" /db_xref="UniProtKB/TrEMBL:A0A1R3Y1Q6" BEGIN 1 MASSTTFVIV GGGLAGAKAV EALRRSDFGG RIILFGDEEH LPYDRPPLSK EFLAGKKSLS 61 DFTIQTSDWY RDHDVDVRLG VRVSSLDRSA HTVELPDGAA VRYDKLLLAT GSAPRRPPIP 121 GSDAAGVHYL RSYNDAVALN SVLVQGSSLA VVGAGWIGLE VAASARQRGV DVTVVETAIQ 181 PLLAALGEAV GKVFADLHRD QGVDLRLQTQ LEEITAADGK ATGLKMRDGS TVAADAVLVA 241 VGAKPNVELA QQAGLAMGEG GVLVDASLRT SDPDIYAVGD IAAAEHPLLG TRVRTEHWAN 301 ALKQPAVAAA GMLGRPGEYA ELPYLFTDQY DLGMEYVGHA PSCDRVVFRG NVAGREFLSF 361 WLDGDSRVLA GMNVNVWDVV DDVKGLIRSG NPVDVDRLVD PQWPLADLTT N //