LOCUS       SIU00504.1               411 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            reductase protein.
ACCESSION   LT708304-1917
PROTEIN_ID  SIU00504.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1900C"
                     /note="Mb1900c, -, len: 411 aa. Equivalent to Rv1869c,
                     len: 411 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 411 aa overlap). Probable reductase
                     (1.-.-.-). Similar to several reductases e.g.
                     CAC04223.1|AL391515 putative ferredoxin reductase from
                     Streptomyces coelicolor (420 aa); THCD_RHOSO|P43494
                     rhodocoxin reductase (426 aa), FASTA scores: opt: 904,
                     E(): 0, (40.8% identity in 370 aa overlap). Also similar
                     to Mycobacterium tuberculosis proteins Rv0688 (406 aa)
                     (39.9% identity in 391 aa overlap); and Rv0253 (nitrite
                     reductase subunit). Protein product from Mb1900c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1900c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3Y1Q6"
                     /db_xref="InterPro:IPR016156"
                     /db_xref="InterPro:IPR023753"
                     /db_xref="InterPro:IPR028202"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3Y1Q6"
BEGIN
        1 MASSTTFVIV GGGLAGAKAV EALRRSDFGG RIILFGDEEH LPYDRPPLSK EFLAGKKSLS
       61 DFTIQTSDWY RDHDVDVRLG VRVSSLDRSA HTVELPDGAA VRYDKLLLAT GSAPRRPPIP
      121 GSDAAGVHYL RSYNDAVALN SVLVQGSSLA VVGAGWIGLE VAASARQRGV DVTVVETAIQ
      181 PLLAALGEAV GKVFADLHRD QGVDLRLQTQ LEEITAADGK ATGLKMRDGS TVAADAVLVA
      241 VGAKPNVELA QQAGLAMGEG GVLVDASLRT SDPDIYAVGD IAAAEHPLLG TRVRTEHWAN
      301 ALKQPAVAAA GMLGRPGEYA ELPYLFTDQY DLGMEYVGHA PSCDRVVFRG NVAGREFLSF
      361 WLDGDSRVLA GMNVNVWDVV DDVKGLIRSG NPVDVDRLVD PQWPLADLTT N
//