LOCUS       SIU00500.1               286 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            SHORT-CHAIN TYPE DEHYDROGENASE protein.
ACCESSION   LT708304-1913
PROTEIN_ID  SIU00500.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB1896C"
                     /note="Mb1896c, -, len: 286 aa. Equivalent to Rv1865c,
                     len: 286 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 286 aa overlap). Probable short-chain
                     dehydrogenase (EC 1.-.-.-), highly similar to C-terminus
                     of NP_301650.1|NC_00267 putative oxidoreductase from
                     Mycobacterium leprae (596 aa). Also similar to various
                     dehydrogenases, generally belonging to short-chain family,
                     e.g. AAG02168.1|AF212041_24|AF212041
                     3-oxoacyl-(acylcarrier protein) reductase from Zymomonas
                     mobilis (251 aa); P50198|LINX_PSEPA
                     2,5-DICHLORO-2,5-CYCLOHEXADIENE-1,4-DIOL DEHYDROGENASE
                     from Sphingomonas paucimobilis (250 aa);
                     NP_105680.1|NC_002678 sorbitol dehydrogenase (also similar
                     to acetoin reductase) from Mesorhizobium loti (256 aa);
                     etc. And highly similar to C-terminus of
                     ephD|Rv2214c|MTCY190.25c from Mycobacterium tuberculosis
                     (592 aa); and many other oxidoreductases from
                     Mycobacterium tuberculosis e.g. Y00P_MYCTU|Q10402 putative
                     oxidoreductase (650 aa), FASTA scores: opt: 439, E():
                     8.9e-20, (32.5% identity in 280 aa overlap). Contains
                     PS00061 Short-chain alcohol dehydrogenase family
                     signature. BELONGS TO THE SHORT-CHAIN
                     DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Protein product
                     from Mb1896c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb1896c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZJ8"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZJ8"
BEGIN
        1 MPGRTSIGVK IRDKVQDKVI AITGGARGIG LATAAALHNL GAKVAIGDID EAMAKESGAD
       61 LDLDMYGKLD VTDPDSFSGF LDAVERQLGP IDVLVNNAGI MPVGRIVDEP DPVTRRILDI
      121 NVYGVILGSK LAAQRMVPRG RGHVINVASL AGEIYAVGVA TYCASKHAVV AFTDSARLEY
      181 RSAGVKFSMV LPSFVNTELI AGTGGIKGFK NAEPADIADA IVGLIVHPKP RVRVTKAAGS
      241 MIVAQRFMPR QVSEGLNRLL GGEHVFTDDV DMEKRRTYEA RARGEE
//