LOCUS       SIU00497.1               346 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Probable
            alcohol dehydrogenase adhA protein.
ACCESSION   LT708304-1910
PROTEIN_ID  SIU00497.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="adhA"
                     /locus_tag="BQ2027_MB1893"
                     /note="Mb1893, adhA, len: 346 aa. Equivalent to Rv1862,
                     len: 346 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 346 aa overlap=. Probable adhA,
                     alcohol dehydrogenase (EC 1.1.1.1), similar to
                     ADH2_BACST|P42327 alcohol dehydrogenase (339 aa), FASTA
                     scores: opt: 630, E(): 2.4e-32 (34.4% identity in 320 aa
                     overlap). Contains PS00059 Zinc-containing alcohol
                     dehydrogenases signature. Protein product from Mb1893
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb1893 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XZX7"
                     /db_xref="InterPro:IPR002328"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="InterPro:IPR014187"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XZX7"
BEGIN
        1 MVSPATTATM SAWQVRRPGP MDTGPLERVT TRVPRPAPSE LLVAVHACGV CRTDLHVTEG
       61 DLPVHRERVI PGHEVVGEVI EVGSAVGAAA GGEFDRGDRV GIAWLRHTCG VCKYCRRGSE
      121 NLCPQSRYTG WDADGGYAEF TTVPAAFAHH LPSGYSDSEL APLLCAGIIG YRSLLRTELP
      181 PGGRLGLYGF GGSAHITAQV ALAQGAEIHV MTRGARARKL ALQLGAASAQ DAADRPPVPL
      241 DAAILFAPVG DLVLPALEAL DRGGILAIAG IHLTDIPDLN YQQHLFQERQ IRSVTSNTRA
      301 DARAFFDFAA QHHIEVTTPE YPLGQADRAL GDLSAGRIAG AAVLLI
//