LOCUS       SIU00485.1               577 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Urease
            alpha subunit ureC (Urea amidohydrolase) protein.
ACCESSION   LT708304-1898
PROTEIN_ID  SIU00485.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ureC"
                     /locus_tag="BQ2027_MB1881"
                     /note="Mb1881, ureC, len: 577 aa. Equivalent to Rv1850,
                     len: 577 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 577 aa overlap). ureC, urease alpha
                     subunit (EC 3.5.1.5). Similar to URE1_MYCTU|P50042 from M.
                     tuberculosis (577 aa), FASTA scores: opt: 3794, E(): 0,
                     (98.3% identity in 577 aa overlap). Contains PS00145
                     Urease active site motif. BELONGS TO THE UREASE FAMILY.
                     Protein product from Mb1881 detected using SWATH mass
                     spectrometry. Mb1881 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A661"
                     /db_xref="InterPro:IPR005848"
                     /db_xref="InterPro:IPR006680"
                     /db_xref="InterPro:IPR011059"
                     /db_xref="InterPro:IPR011612"
                     /db_xref="InterPro:IPR017950"
                     /db_xref="InterPro:IPR017951"
                     /db_xref="InterPro:IPR029754"
                     /db_xref="InterPro:IPR032466"
                     /db_xref="UniProtKB/Swiss-Prot:P0A661"
BEGIN
        1 MARLSRERYA QLYGPTTGDR IRLADTNLLV EVTEDRCGGP GLAGDEAVFG GGKVLRESMG
       61 QGRASRADGA PDTVITGAVI IDYWGIIKAD IGIRDGRIVG IGKAGNPDIM TGVHRDLVVG
      121 PSTEIISGNR RIVTAGTVDC HVHLICPQII VEALAAGTTT IIGGGTGPAE GTKATTVTPG
      181 EWHLARMLES LDGWPVNFAL LGKGNTVNPD ALWEQLRGGA SGFKLHEDWG STPAAIDTCL
      241 AVADVAGVQV ALHSDTLNET GFVEDTIGAI AGRSIHAYHT EGAGGGHAPD IITVAAQPNV
      301 LPSSTNPTRP HTVNTLDEHL DMLMVCHHLN PRIPEDLAFA ESRIRPSTIA AEDVLHDMGA
      361 ISMIGSDSQA MGRVGEVVLR TWQTAHVMKA RRGALEGDPS GSQAADNNRV RRYIAKYTIC
      421 PAIAHGMDHL IGSVEVGKLA DLVLWEPAFF GVRPHVVLKG GAIAWAAMGD ANASIPTPQP
      481 VLPRPMFGAA AATAAATSVH FVAPQSIDAR LADRLAVNRG LAPVADVRAV GKTDLPLNDA
      541 LPSIEVDPDT FTVRIDGQVW QPQPAAELPM TQRYFLF
//