LOCUS SIU00485.1 577 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Urease alpha subunit ureC (Urea amidohydrolase) protein. ACCESSION LT708304-1898 PROTEIN_ID SIU00485.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ureC" /locus_tag="BQ2027_MB1881" /note="Mb1881, ureC, len: 577 aa. Equivalent to Rv1850, len: 577 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 577 aa overlap). ureC, urease alpha subunit (EC 3.5.1.5). Similar to URE1_MYCTU|P50042 from M. tuberculosis (577 aa), FASTA scores: opt: 3794, E(): 0, (98.3% identity in 577 aa overlap). Contains PS00145 Urease active site motif. BELONGS TO THE UREASE FAMILY. Protein product from Mb1881 detected using SWATH mass spectrometry. Mb1881 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P0A661" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="UniProtKB/Swiss-Prot:P0A661" BEGIN 1 MARLSRERYA QLYGPTTGDR IRLADTNLLV EVTEDRCGGP GLAGDEAVFG GGKVLRESMG 61 QGRASRADGA PDTVITGAVI IDYWGIIKAD IGIRDGRIVG IGKAGNPDIM TGVHRDLVVG 121 PSTEIISGNR RIVTAGTVDC HVHLICPQII VEALAAGTTT IIGGGTGPAE GTKATTVTPG 181 EWHLARMLES LDGWPVNFAL LGKGNTVNPD ALWEQLRGGA SGFKLHEDWG STPAAIDTCL 241 AVADVAGVQV ALHSDTLNET GFVEDTIGAI AGRSIHAYHT EGAGGGHAPD IITVAAQPNV 301 LPSSTNPTRP HTVNTLDEHL DMLMVCHHLN PRIPEDLAFA ESRIRPSTIA AEDVLHDMGA 361 ISMIGSDSQA MGRVGEVVLR TWQTAHVMKA RRGALEGDPS GSQAADNNRV RRYIAKYTIC 421 PAIAHGMDHL IGSVEVGKLA DLVLWEPAFF GVRPHVVLKG GAIAWAAMGD ANASIPTPQP 481 VLPRPMFGAA AATAAATSVH FVAPQSIDAR LADRLAVNRG LAPVADVRAV GKTDLPLNDA 541 LPSIEVDPDT FTVRIDGQVW QPQPAAELPM TQRYFLF //